HOME >> BIOLOGY >> NEWS
Genomic data viewed on biological pathways with new computer program, GenMAPP

and Gladstone postodoctoral fellow. "The long-term goal is to have MAPPs representing all biological pathways so we can use a systems approach to analyze gene expression data and thus see the big picture."

The most widespread method of analyzing gene expression data is called hierarchical clustering, which groups together genes with similar levels of expression. This method is powerful because it groups genes together without any prior knowledge of the genes function. GenMAPP takes an opposite, complementary approach. By looking at genes in the context of a known biological process, it is possible to make sense of data that would otherwise be uninterpretable.

Furthermore, small changes in gene expression may be missed in hierarchical clustering, yet have real meaning when displayed on a biological pathway. Hierarchical clustering and the pathway-based GenMAPP work together to help in interpreting biological data.

"This is part of a larger process of putting all the pieces together and has tremendous value for figuring out diseases," Conklin said.

Currently GenMAPP is the only free available program for drawing, viewing, and sharing pathway information in a format that can be used with gene expression data. There are no barriers for any scientist to use the program to modify MAPPs according to his or her hypothesis, to design new pathways and to share the data with others in the community. Conklin said that he hopes that GenMAPP becomes a standard means of viewing microarray data, and pathway information. Already, researchers are using GenMAPP to display results in conferences and published papers. By providing a common format to present and share data, Conklin said that he hopes that GenMAPP will help biologists communicate.

"This puts us one step closer to a common goal of trying to determine how we put all the pieces of the biological puzzle together," he said.


'"/>

Contact: Laura Lane
llane@gladstone.ucsf.edu
415-695-3833
University of California - San Francisco
6-May-2002


Page: 1 2 3

Related biology news :

1. NIH launches first center in Nationwide Chemical Genomics Network
2. Genomic biology institutes first grant to focus on soybeans, climate change
3. Genomic imprinting in disruptive spermatogenesis
4. Genomic changes reveal evolution of SARS virus
5. Evolutionary Genomics meeting in Tucson
6. New Columbia Genomic Center of Excellence aims to speed genetic targeting of medicines
7. Monitoring malaria: Genomic activity of the parasite in human blood cells
8. On tap: Genomic sequence of an enemy of beer and bread
9. Moffitt Cancer Center receives DoD funds to establish National Functional Genomics Project
10. Genomics and world peace
11. Consortium for Archaeal Genomics and Proteomics established at Penn State

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
(Date:6/2/2016)... -- Perimeter Surveillance & Detection Systems, Biometrics ... Support & Other Service  The latest report ... analysis of the global Border Security market . ... $17.98 billion in 2016. Now: In November ... software and hardware technologies for advanced video surveillance. ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is ... partnership with VoicePass. By working together, ... experience.  Because VoiceIt and VoicePass take slightly different ... engines increases both security and usability. ... excitement about this new partnership. "This ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... UAS ... the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The company, ... proud to add Target to its list of well-respected retailers. This list includes ...
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
(Date:6/23/2016)... 2016   EpiBiome , a precision microbiome engineering ... debt financing from Silicon Valley Bank (SVB). The financing ... advance its drug development efforts, as well as purchase ... "SVB has been an incredible strategic partner to us ... bank would provide," said Dr. Aeron Tynes Hammack ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
Breaking Biology Technology:
Cached News: