HOME >> BIOLOGY >> NEWS
Germany starts clinical development of a new tuberculosis vaccine

This press release is also available in German.

To mark World Tuberculosis Day on March 24th, a consortium of business and research centres have launched a programme to develop just such a vaccine. Scientists at the Max Planck Institute for Infection Biology (MPIIB) in Berlin, under the direction of Prof. Stefan H. E. Kaufmann, have developed a highly promising vaccine candidate. And now, Vakzine Projekt Management GmbH (VPM) has acquired a worldwide licence for several patents from Max Planck Society. VPM was founded by Germany's Federal Ministry for Education and Research (BMBF) as part of a national vaccine initiative. In collaboration with MPIIB and the German Rearch Centre for Biotechnology (GBF) VPM will manage the pre-clinical and clinical study program.

"For our new tuberculosis vaccine candidates we are relying on genetically modified variants of the live BCG vaccine that has been in use since 1921," says MPI director, Prof. Dr. Stefan Kaufmann. "The vaccine consists of an attenuated bacteria that is very closely related to the TB pathogen, Mycobacterium tuberculosis. BCG has a proven safety record for many decades, but unfortunately it lacks effectiveness," notes Kaufmann, adding that children can be protected against certain forms of TB only. There is no protection at all against pneumotuberculosis, by far the most common form of the disease.

The protection provided by the presently existing BCG vaccine is assumed to be limited because the BCG bacteria are hidden in the body cells inside so-called phagosomes. The group of Professor Kaufmann, therefore, has inserted a gene coding for the protein listeriolysin. "This protein causes perforation of the phagosomes thus making BCG cells available to the immune system to build up immune protection," says Dr. Leander Grode, now project manager at VPM and co-inventor of the new strain. "Preclinical expe
'"/>

Contact: Dr. Sabine Englich
englich@mpiib-berlin.mpg.de
0049 30 28460 142
Max-Planck-Gesellschaft
24-Mar-2004


Page: 1 2

Related biology news :

1. The amendment to the law on green Genetic Engineering inhibits innovation and research in Germany
2. Scientists in Germany and Hebrew University illuminate process in control of flowering in plants
3. Sex selection for social reasons unlikely to skew gender balance in Germany and UK
4. The DFG announces EURYI Awards for Germany
5. Portuguese teacher gets hands-on look at cutting-edge research at EMBL, Germany
6. ART laws put patients at risk and should be changed, warns head of Germanys IVF registry
7. First clinical trial of intravenous rViscumin under way in Germany and France
8. Health care rationing in Germany
9. Humboldt awarded for study of acid-mine drainage in Germany
10. Germany needs a national genome initiative
11. From Germany To The Wild West: Geologists Hunt For Evidence Of Ancient Crinoid

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2018)... ... , ... Today, the FSH Society , the world’s largest research-focused patient ... holding its 3rd annual Walk & Roll to Cure FSHD in Castle ... for public awareness and is raising funds to support the Society’s work. , The ...
(Date:8/15/2018)... ... 2018 , ... Exalto Bearings UK , the manufacturer of high quality ... ISO quality management certification to BS EN ISO 9001:2015. This ISO standard is based ... company’s ability to offer products and services of consistent high quality. , Over the ...
(Date:8/14/2018)... ... 13, 2018 , ... Career fairs provide an ideal setting ... systems at once. However, healthcare professionals often have hectic schedules with little spare ... healthcare providers who wish to explore opportunities and learn about multiple employers from ...
Breaking Biology News(10 mins):
(Date:9/7/2018)... ... , ... Akadeum Life Sciences today announced it has appointed George Dunbar to ... of numerous biotech companies. , He most recently served as president and CEO ... Capital in St. Louis, MO. Prior to ISTO, he was a Venture Partner ...
(Date:8/29/2018)... ... 2018 , ... Cognition Corporation ®, a software company specializing in medical ... . , Ryan Ward, Director of Engineering at Zimmer Biomet, has been announced ... and manager with Zimmer Biomet for almost 15 years, Mr. Ward will focus his ...
(Date:8/26/2018)... ... August 23, 2018 , ... LabRoots , ... from around the world, will host the 4th Annual Microbiology and Immunology Virtual ... and disciplines, encompassing various research areas including medicine, agriculture, and space. , ...
(Date:8/21/2018)... ... 21, 2018 , ... The Connecticut Technology Council (CTC) and Marcum LLP today ... technology companies in Connecticut. This year’s group of top-ranked companies will be honored at ... Connecticut Convention Center in Hartford. A complete list of the Marcum Tech Top 40 ...
Breaking Biology Technology:
Cached News: