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Gestational diabetes not found to alter the metabolic processes in obese pregnant women

nucleus of the hypothalamus to curb appetite and increase energy expenditure as body fat stores increase) concentrations in pregnancy has not yet been fully explained, the research team examined the relationship of maternal serum leptin changes in nutrient metabolism.

The authors of the study, Longitudinal Changes in Energy Expenditure and Body Composition in Obese Women with Normal and Impaired Glucose Tolerance, are Ndubueze C. Okereke, Larraine Huston-Presley, Saeid B. Amini, Satish Kalhan, and Patrick M. Catalano, all from Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH. Their findings appear in the online edition of the American Journal of PhysiologyXEndocrinology and Metabolism. The journal is one of 14 published each month by the American Physiological Society (www.the-aps.org).

Methodology

Fifteen healthy obese women (defined as pre-pregnancy percent body fat greater than 25 percent) were recruited before a planned pregnancy to participate in this study. None of the subjects were breast-feeding or using hormonal contraception, tobacco, or other medications that might affect carbohydrate metabolism or energy expenditure. None of the study subjects had diabetes mellitus before conception; seven of the women were at high risk of developing GDM, based on a history of GDM in a previous pregnancy (n=4), a strong family history of type 2 diabetes in a first-degree relative (n=2), or an impaired glucose tolerance test before conception plus a first-degree relative with type 2 diabetes (n=1). Other than GDM, the pregnancies were uncomplicated. Eight other women were recruited, none of whom had a history of abnormal glucose tolerance either before or during a previous pregnancy (i.e., the NGT group). All subjects were planning to conceive as soon as the baseline pre-pregnancy studies were completed.

Each subject was evaluated before conception (P), in early (E) gestation (12-14 weeks) and again in
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Contact: Mayer Resnick
mresnick@the-aps.org
301-634-7209
American Physiological Society
22-Jun-2004


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