HOME >> BIOLOGY >> NEWS
Get your blood moving: Increased blood flow could lead to healthier blood vessels

(Philadelphia, PA) Scientists have found a new way in which exercise may protect against heart disease. Increased blood flow can mimic the powerful anti-inflammatory actions of certain glucocorticoid steroid drugs, according to researchers at the University of Pennsylvania's Institute for Medicine and Engineering. The researchers discovered that an increase in shear stress the drag force exerted by blood flowing over endothelial cells that line blood vessels results in the same sort of anti-inflammatory events normally associated with high doses of steroids.

Their findings will be presented in the January 24th online edition of Circulation Research: Journal of the American Heart Association, followed by the print edition of the journal on February 21st.

"Inflammation in blood vessels has been linked to atherosclerosis, a hardening of the arteries, and here we see how the physical force of blood flow can cause cells to produce their own anti-inflammatory response," said Scott L. Diamond, PhD, director of the Penn's Biotechnology Program and a professor of chemical and biomolecular engineering at Penn's School of Engineering and Applied Science. "Conceivably, exercise provides the localized benefits of glucocorticoids just as potent as high doses of steroids, yet without all the systemic side effects of taking the drugs themselves."

"Perhaps this is a natural way in which exercise helps protect the vessels, by stimulating an anti-inflammatory program when the vessels are exposed to elevated blood flow. We're not talking about running a marathon here, we're just talking about getting the blood moving at high arterial levels," said Diamond.

It is the first direct evidence that the mechanical effects of blood flow have anti-inflammatory properties. According to their findings, shear stress can activate glucocorticoid receptors (GR) to enter the nucleus of the cells, an event normally triggered by glucocorticoid steroids.
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
23-Jan-2003


Page: 1 2

Related biology news :

1. Experimental drug shown to block mutant protein causing blood disease
2. IBD (Crohns, Colitis) joins cancer, inflammatory diseases in associated blood vessel growth
3. A probable cause for high blood pressure identified - shows links with diabetes
4. Probing the surface of white blood cells to enhance immune system medicine
5. Streptococcus infects humans by thwarting blood clotting
6. Strep disrupts blood clotting to infect humans
7. Nucleic acid-amplification testing further safeguards nations blood supply
8. Hopkins scientists use blood proteins to detect ovarian cancer
9. Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
10. Oxygen sensing in worms may hold key to healthy blood pressure in humans
11. Mouse brain stem cells capable of converting into blood vessel cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... --  The Weather Company , an IBM Business (NYSE: ... in which consumers will be able to interact with IBM ... voice or text and receive relevant information about the product ... have long sought an advertising solution that can create a ... and valuable; and can scale across millions of interactions and ...
(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)... Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator (YI) ... of the Class of 2016 were selected from a pool of 128 applicants ... the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... launch of the Supplyframe Design Lab . Located in Pasadena, Calif., the ... future of how hardware projects are designed, built and brought to market. , ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology:
Cached News: