Get your blood moving: Increased blood flow could lead to healthier blood vessels

(Philadelphia, PA) Scientists have found a new way in which exercise may protect against heart disease. Increased blood flow can mimic the powerful anti-inflammatory actions of certain glucocorticoid steroid drugs, according to researchers at the University of Pennsylvania's Institute for Medicine and Engineering. The researchers discovered that an increase in shear stress the drag force exerted by blood flowing over endothelial cells that line blood vessels results in the same sort of anti-inflammatory events normally associated with high doses of steroids.

Their findings will be presented in the January 24th online edition of Circulation Research: Journal of the American Heart Association, followed by the print edition of the journal on February 21st.

"Inflammation in blood vessels has been linked to atherosclerosis, a hardening of the arteries, and here we see how the physical force of blood flow can cause cells to produce their own anti-inflammatory response," said Scott L. Diamond, PhD, director of the Penn's Biotechnology Program and a professor of chemical and biomolecular engineering at Penn's School of Engineering and Applied Science. "Conceivably, exercise provides the localized benefits of glucocorticoids just as potent as high doses of steroids, yet without all the systemic side effects of taking the drugs themselves."

"Perhaps this is a natural way in which exercise helps protect the vessels, by stimulating an anti-inflammatory program when the vessels are exposed to elevated blood flow. We're not talking about running a marathon here, we're just talking about getting the blood moving at high arterial levels," said Diamond.

It is the first direct evidence that the mechanical effects of blood flow have anti-inflammatory properties. According to their findings, shear stress can activate glucocorticoid receptors (GR) to enter the nucleus of the cells, an event normally triggered by glucocorticoid steroids.

Contact: Greg Lester
University of Pennsylvania School of Medicine

Page: 1 2

Related biology news :

1. Experimental drug shown to block mutant protein causing blood disease
2. IBD (Crohns, Colitis) joins cancer, inflammatory diseases in associated blood vessel growth
3. A probable cause for high blood pressure identified - shows links with diabetes
4. Probing the surface of white blood cells to enhance immune system medicine
5. Streptococcus infects humans by thwarting blood clotting
6. Strep disrupts blood clotting to infect humans
7. Nucleic acid-amplification testing further safeguards nations blood supply
8. Hopkins scientists use blood proteins to detect ovarian cancer
9. Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
10. Oxygen sensing in worms may hold key to healthy blood pressure in humans
11. Mouse brain stem cells capable of converting into blood vessel cells

Post Your Comments:

(Date:10/29/2015)... , Oct. 29, 2015 Today, ... announced a partnership with 2XU, a global leader ... deliver a smart hat with advanced bio-sensing technology. ... other athletes to monitor key biometrics to improve ... strategic partnership, the two companies will bring together the ...
(Date:10/27/2015)... 2015 Munich, Germany ... technology (ASGM) automatically maps data from mobile eye tracking ... , so that they can be quantitatively analyzed with ... Munich, Germany , October 28-29, 2015. SMI,s Automated ... mobile eye tracking videos created with SMI,s Eye ...
(Date:10/26/2015)... , October 26, 2015 ... --> ReportnsReports.com adds Biometrics Market ... 2021 as well as Emerging Biometrics ... reports to its collection of IT ... . --> http://www.reportsnreports.com/reports/427352-biometrics-market-shares-market-strategies-and-market-forecasts-2015-to-2021.html ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Nov. 25, 2015  PharmAthene, Inc. (NYSE MKT: PIP) ... a stockholder rights plan (Rights Plan) in an effort ... carryforwards (NOLs) under Section 382 of the Internal Revenue ... PharmAthene,s use of its NOLs could be substantially ... defined in Section 382 of the Code. In general, ...
(Date:11/25/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS; TSX: AEZ) ... remain fundamentally strong and highlights the following developments: ... DSMB recommendation to continue the ZoptEC Phase 3 ... final interim efficacy and safety data , ... with heavily pretreated castration- and Taxane-resistant prostate cancer ...
(Date:11/24/2015)... 24, 2015  Asia-Pacific (APAC) holds the third-largest ... market. The trend of outsourcing to low-cost locations ... higher volume share for the region in the ... margins in the CRO industry will improve. ... ( http://www.frost.com/sublib/display-report.do?id=P86A-01-00-00-00&src=PR ), finds that the market earned ...
(Date:11/24/2015)... ... 2015 , ... Copper is an essential micronutrient that all ... copper is also toxic to cells. With a $1.3 million award from the ... a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), a ...
Breaking Biology Technology:
Cached News: