HOME >> BIOLOGY >> NEWS
Get your blood moving: Increased blood flow could lead to healthier blood vessels

(Philadelphia, PA) Scientists have found a new way in which exercise may protect against heart disease. Increased blood flow can mimic the powerful anti-inflammatory actions of certain glucocorticoid steroid drugs, according to researchers at the University of Pennsylvania's Institute for Medicine and Engineering. The researchers discovered that an increase in shear stress the drag force exerted by blood flowing over endothelial cells that line blood vessels results in the same sort of anti-inflammatory events normally associated with high doses of steroids.

Their findings will be presented in the January 24th online edition of Circulation Research: Journal of the American Heart Association, followed by the print edition of the journal on February 21st.

"Inflammation in blood vessels has been linked to atherosclerosis, a hardening of the arteries, and here we see how the physical force of blood flow can cause cells to produce their own anti-inflammatory response," said Scott L. Diamond, PhD, director of the Penn's Biotechnology Program and a professor of chemical and biomolecular engineering at Penn's School of Engineering and Applied Science. "Conceivably, exercise provides the localized benefits of glucocorticoids just as potent as high doses of steroids, yet without all the systemic side effects of taking the drugs themselves."

"Perhaps this is a natural way in which exercise helps protect the vessels, by stimulating an anti-inflammatory program when the vessels are exposed to elevated blood flow. We're not talking about running a marathon here, we're just talking about getting the blood moving at high arterial levels," said Diamond.

It is the first direct evidence that the mechanical effects of blood flow have anti-inflammatory properties. According to their findings, shear stress can activate glucocorticoid receptors (GR) to enter the nucleus of the cells, an event normally triggered by glucocorticoid steroids.
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
23-Jan-2003


Page: 1 2

Related biology news :

1. Experimental drug shown to block mutant protein causing blood disease
2. IBD (Crohns, Colitis) joins cancer, inflammatory diseases in associated blood vessel growth
3. A probable cause for high blood pressure identified - shows links with diabetes
4. Probing the surface of white blood cells to enhance immune system medicine
5. Streptococcus infects humans by thwarting blood clotting
6. Strep disrupts blood clotting to infect humans
7. Nucleic acid-amplification testing further safeguards nations blood supply
8. Hopkins scientists use blood proteins to detect ovarian cancer
9. Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
10. Oxygen sensing in worms may hold key to healthy blood pressure in humans
11. Mouse brain stem cells capable of converting into blood vessel cells

Post Your Comments:
(Date:8/18/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/9dmm6l/global_biometric ... "Global Biometric Authentication & Identification Market: Focus On ... 2015-2020" report to their offering. ... market is expected to grow at an estimated ... generate over $25 billion (approximately) by 2020 as ...
(Date:8/12/2015)... Calif. , Aug. 12, 2015  Synaptics ... of human interface solutions, today announced that four ... announced Match-in-Sensor solution, have officially been named FIDO ... As part of the certification, Synaptics, Natural ID™ ... 1.0 Universal Authentication Framework (UAF) standard and are ...
(Date:8/6/2015)... BOSTON and TELTOW, Germany ... the 2015 Siggraph Conference, SensoMotoric Instruments (SMI) ... augmented reality , based on Epson,s Moverio ... eye tracking platform. With this new solution, unprecedented quality ... multi-modal, hands-free interaction with context-sensitive displays. For the first ...
Breaking Biology News(10 mins):Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3
(Date:8/28/2015)... ... ... initial launch of FireflySci Inc. (FFS) in early 2015, the company continues to shake up ... the Fonz in a lab coat and Large Marge have been posted on the company’s ... , FireflySci is proud to be the only cuvette manufacturer is the world that has ...
(Date:8/27/2015)... - Portage Biotech Inc. ("Portage") (OTC Market: PTGEF, ... Company Limited (Biohaven), announced today that dosing has ... a glutamate modulating agent. Biohaven filed an investigational ... clearance from the U.S. Food and Drug Administration ... 54% equity interest in Biohaven, a private company. ...
(Date:8/27/2015)... SAN DIEGO , Aug. 27, 2015 ... second annual meeting of the Japan Society of HTLV-1, ... Science Institute Auditorium. The purpose of the Society is ... well as the development of medical technology and research ... health and welfare. "HUYA is proud to ...
(Date:8/27/2015)... PARK, N.C. , Aug. 27, 2015 /PRNewswire/ ... the decision by FedEx, UPS and The US ... certain biological specimens classified as ,select agents, by ... long history of handling these sensitive shipments. ... of global transportation regulations, trained and certified personnel ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Marken Ensures Safe Transportation Of Select Agents And Toxins 2
Cached News: