HOME >> BIOLOGY >> NEWS
Gladstone/UCSF team discovers interaction of two brain proteins may be key factor in development of Alzheimer's disease

ous systems that affects some four million Americans and is the fourth leading cause of death among adults in the U.S. It causes progressive mental deterioration that culminates in dementia, robbing people of their ability to think and share thoughts with others. There is no cure, and current treatments offer only limited hope of alleviating the devastating effects of the disease.

The cells in this study were neurons, which are necessary for the processing and storage of information in the brain. They had been genetically altered to express wild-type human APP or a mutant APP found in a type of early-onset AD that runs in families. When the neurons were exposed to stimuli that induce cell death, wild-type APP--but not mutant APP--protected the cells by inhibiting the ability of p53 to switch on the cell suicide machinery. "The inability of mutant APP to control p53 activation may help to explain, at least in part, why Alzheimer's-linked APP mutations result in the early onset of neurodegenerative disease," Mucke said. "The next step will be to determine if the APP mutations directly impair the protective function of APP or rather counteract it by increasing a neurotoxic APP breakdown product."

The new research findings relate to an earlier study by Mucke, Roger Nicoll, MD, UCSF professor of pharmacology and physiology, and their colleagues in the UCSF neuroscience program. Published in the March 1999 issue of PNAS, it focused on the amyloid-beta peptide, or A-beta, a breakdown product of APP.

Production of A-beta is increased by AD-linked APP mutations. The peptide accumulates in the brains of Alzheimer's victims, forming roundish deposits, called plaques, which have long been suspected of causing the memory loss and disturbed thinking that characterize the disease.

A correlation between cognitive decline and accumulation of A-beta in brain plaques has been reported by some researchers, but many other scien
'"/>

Contact: Corinna Kaarlela
ckaarlela@pubaff.ucsf.edu
415-476-3804
University of California - San Francisco
22-Jun-1999


Page: 1 2 3 4

Related biology news :

1. New Gladstone/UCSF study finds inhibiting fat synthesis results in obesity resistance in mice
2. LSU researcher discovers new bird
3. MIT team discovers memory mechanism
4. OHSU team discovers compound that lacks estrogens risks
5. SMCM professor discovers cattle hormones that leak into streams and alter fish reproduction
6. UBC researcher discovers control room that regulates immune responses
7. UC Santa Barbara discovers cell survival gene may lead to treatments for degenerative diseases
8. Brain patterns the same whether doing or just watching, Queens researcher discovers
9. Study discovers key to baby-like skin
10. Rutgers researcher discovers melanoma causing gene
11. UI study discovers cells segregate molecules to control signaling

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: