Glowing bacteria show researchers how an anti-flu-virus drug may prevent bacterial...( ess intense and not localized in specif...)

Glowing bacteria show researchers how an anti-flu-virus drug may prevent bacterial pneumonia

ess intense and not localized in specific areas. This suggested that the immune system of the infected mice was able to kill many of the bacteria that were "stranded" outside the cell membrane in oseltamivir-treated animals.

Untreated mice developed pneumonia earlier than treated mice and died. In treated mice, even when infection spread, the progression of the disease was slower than in untreated mice, and up to half of the treated animals survived.

When the researchers studied the effect of oseltamivir using human lung cells in a dish, they found that the drug blocked the binding of streptococcus to these cells by interfering with NA, similar to the findings in mice.

The article's co-author is Rhodes College pre-med student Kimberly A. Bartmess, who works in Dr. McCullers' lab as a part of the St. Jude Rhodes Summer Plus Program.

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Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
7-Mar-2003

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