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Gout drug could offer hope for heart failure patients

A medication commonly used for gout holds possibilities for the treatment of heart failure, Johns Hopkins researchers report. It's a drug that works by a new principle, namely, directly decreasing heart muscle's need for energy and making it contract more efficiently.

When allopurinol was injected into the hearts of nine patients with congestive heart failure, it significantly improved the organs' efficiency. Results are reported in the Nov. 13 issue of Circulation, an American Heart Association journal.

Heart failure can be compared to a car that's out of tune. The heart still functions, but it's not efficient. As the heart worsens, it must work harder, requiring stepped-up, energy-producing reactions that enable it to contract and pump blood. In the Hopkins study, allopurinol improved overall heart efficiency. The hearts of patients treated with the medication had a 20 percent reduction in energy consumption with no reduction in contraction strength.

"Allopurinol represents a novel potential strategy for the treatment of heart failure," says Joshua M. Hare, M.D., senior author of the study and director of Hopkins' heart failure research program. "It allowed the heart to use less oxygen without any detrimental effects on its function."

For the study, Hare and colleagues looked at nine patients (seven men and two women) with dilated cardiomyopathy a cause of severe heart failure in which the lower left chamber of the heart becomes enlarged and weakened. Patients were taking standard medications for congestive heart failure, including ACE inhibitors and beta blockers.

Allopurinol was infused directly into the heart while researchers recorded the patients' heart performance. The research team also took tissue samples from cardiomyopathy patients undergoing heart transplant and used them to measure amounts of xanthine oxidase (XO) an enzyme involved in normal tissue metabolism.

XO contributes
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Contact: Karen Blum
kblum@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
12-Nov-2001


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