Grant strengthens research arm of Penn State Hershey Medical Center's ALS Clinic

lar diseases and look for the prevalence of the mutated form of the Hfe gene in the two groups. A mutation in the Hfe gene has been linked with a condition called hemachromatosis, which causes too much iron to accumulate in the tissues. People can be carriers of the mutant Hfe gene and yet have no symptoms of hemachromatosis. However, the organs (e.g. liver, heart, brain) of these individuals may still mishandle iron and as a result can produce free radicals. Free radicals are toxic forms of oxygen that result when iron interacts with oxygen in the body. These toxins can indiscriminately kill healthy cells. This process, called oxidative stress, is considered a contributor to the disease process in ALS.

Connor and Simmons will test the hypothesis that Hfe mutations are associated with an earlier onset of ALS and a more rapid disease progression. A second part of the study will investigate distribution and levels of expression of Hfe in tissue collected at autopsy from the brains and spinal cords of those with and without ALS. Finally, because the researchers hypothesize that the presence of an Hfe mutation increases the amount of oxidative damage, they will measure the amount of oxidative stress markers in autopsy samples from those with ALS and the Hfe mutation, and compare it to samples from patients with ALS without the mutation. An important component of ALS research is organ and tissue donation when a person with ALS dies.

"We deeply appreciate such donations, and fully realize what valuable gifts these are," Simmons said. "We believe there are exciting therapeutic opportunities that may result from our study. If our hypothesis proves correct, those patients with ALS who possess the Hfe mutation could be counseled to reduce dietary iron intake and may respond particularly well to antioxidant therapy."


Contact: Valerie Gliem
Penn State

Page: 1 2

Related biology news :

1. Grant advances biochemical engineering laboratory
2. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
3. Grant from GE Foundation to University of Houston to strengthen math, tech pipeline
4. McGill Centre for Intellectual Property Policy receives $3 million SSHRC Grant
5. Grant promotes marine ornamental fish aquaculture
6. Grant of powerful computer to Rutgers-Newark will increase understanding of brain activity
7. Grant renews funding of research toward cloning primates
8. Lipids get the spotlight in new NIGMS Glue Grant
9. Grant funds research to develop tissue-engineered solutions for heart disease
10. Sea Grant News & Notes for March 26, 2003
11. Grant funds research to develop microbicide barrier to HIV

Post Your Comments:

(Date:11/11/2019)... ... November 11, 2019 , ... MicroGenDX, the world leader in ... in the award-winning study “Next Generation Sequencing for the Diagnosis of Periprosthetic Knee ... processed samples using Next Generation DNA Sequencing to examine the ability of NGS ...
(Date:11/6/2019)... Va. (PRWEB) , ... November 06, 2019 , ... ... today that Donald Stanski, MD, a senior pharmaceutical industry executive with expertise in ... and simulation for drug and disease strategic data analytics, has joined the firm ...
(Date:11/5/2019)... WA (PRWEB) , ... November 05, 2019 , ... ... & Amato Dentistry, providing state-of-the-art cosmetic and restorative dentistry to Seattle, WA, including ... her Doctor of Dental Surgery degree from the University of Washington, Dr. Kopp ...
Breaking Biology News(10 mins):
(Date:11/27/2019)... ... November 25, 2019 , ... Silony Medical, a medical ... and navigated surgery in the UK. The procedure was performed in the UK’s ... Syed Aftab and Dr. Alexander Montgomery. The surgery, which took place on July ...
(Date:11/20/2019)... ... November 20, 2019 , ... Defense and ... microturbine electrical power generation units from 2019-2028. The value of this production is ... of 3,821 units worth $569 million. , Reference to 2017 is important, ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... R&D, today announced that Immatics Biotechnologies , a clinical-stage biopharmaceutical company ... to streamline their R&D operations related to the discovery and development of ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... to educate Americans about the deadly healthcare-associated infection C. diff. The campaign, ... of the epidemic, which kills at least 30,000 people in the U.S. each ...
Breaking Biology Technology:
Cached News: