Growing neurons use silencing mechanism to avoid disastrous tug-of-war

March 9, 2001—Just as traffic signals switch off the red light when the green light comes on, the tips of growing nerve cells protect themselves from being led astray by switching off their sensitivity to an attractant protein when activating sensitivity to a repellent protein. This interlocking fail-safe mechanism might be a basic strategy used throughout the central nervous system to avoid the disastrous consequences of a tug-of-war between signals that attract and repel neurons. The discovery might also help explain why spinal cord neurons cannot be easily induced to regenerate after injury, said the researchers.

The discovery was reported by Howard Hughes Medical Institute investigator Marc Tessier-Lavigne and lead author Elke Stein in the March 9, 2001, issue of the journal Science.

Neurons wire themselves into networks by extending cable-like axons that grow toward specific targets in the nervous system. An axon’s path towards a target neuron is steered by growth cones in the tip of the axon that receive cues about the best path to follow from chemical attractants and repellents secreted by cells in the nervous system.

Tessier-Lavigne and his colleagues at the University of California, San Francisco, had previously identified a key attractant protein called netrin-1. Netrin-1 exerts its influence on growth cones by plugging into a receptor called DCC that nestles in the cell membrane. Conversely, a repellent protein called Slit triggers axons to grow away from a site by plugging into a receptor called Robo. Thus, a growing axon is attracted by netrin to a target way station in the spinal cord and then repelled from it toward the next way station by Sli

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3 4

Related biology news :

1. Growing pains: T. Rex was teenage giant
2. Growing new breed of vaccine-producing plants to fight human diseases worldwide
3. Growing replacement teeth and dental tissues
4. Growing human organs on the farm
5. Growing human antibodies in algae
6. Growing Up On Their Own: Smart Plastics Organize Themselves Into Useful Optical Devices
7. Colorado State University Study Reveals Climate Change, Longer Growing Seasons Could Harm Grazing On Western Shortgrass Steppe
8. DNA Helps Track Origins Of Growing Blight Problem
9. Introduction of the Rett protein in post-mitotic neurons rescues Rett Syndrome in mice
10. New study may explain how fats damage neurons in Alzheimers patients
11. Healthy neighbors rescue degenerating motor neurons

Post Your Comments:

(Date:8/26/2020)... (PRWEB) , ... August 25, ... ... clinical-stage biotechnology company developing novel pharmaceuticals targeting mitochondria, in partnership with Essex ... enrolment in its pivotal U.S. Phase 3 VISTA-2 study of SkQ1 ophthalmic ...
(Date:8/23/2020)... (PRWEB) , ... August 21, 2020 , ... ... Rigaku Corporation has been published and is now available on the company’s ... X-ray diffraction—serves the X-ray analysis community, presenting current news and crystallographic research. ...
(Date:8/21/2020)... ... August 19, 2020 , ... ... conference and expo uniting life science, data science, informatics and IT leaders goes ... “In this period of uncertainty and change, Bio-IT takes the leadership role of ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions its ... MediVet Biologics since its formation in 2016, the company is relaunching itself under the ... on its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... that can combine up to three different materials for use with CRM, neurostimulation, ... up to three materials to meet specific design requirements, performance, and cost criteria; ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... life sciences industry, today announced the release of its signature product called ... Science Liaisons (MSLs) and other field medical professionals. , Beacon helps ...
(Date:7/18/2020)... DAYTON, Ohio (PRWEB) , ... July 16, 2020 ... ... clinical data solutions to aid in the early detection and prevention of high-burden ... partnership to enable US-based hospitals and healthcare organizations to utilize existing data in ...
Breaking Biology Technology:
Cached News: