Growing neurons use silencing mechanism to avoid disastrous tug-of-war

March 9, 2001—Just as traffic signals switch off the red light when the green light comes on, the tips of growing nerve cells protect themselves from being led astray by switching off their sensitivity to an attractant protein when activating sensitivity to a repellent protein. This interlocking fail-safe mechanism might be a basic strategy used throughout the central nervous system to avoid the disastrous consequences of a tug-of-war between signals that attract and repel neurons. The discovery might also help explain why spinal cord neurons cannot be easily induced to regenerate after injury, said the researchers.

The discovery was reported by Howard Hughes Medical Institute investigator Marc Tessier-Lavigne and lead author Elke Stein in the March 9, 2001, issue of the journal Science.

Neurons wire themselves into networks by extending cable-like axons that grow toward specific targets in the nervous system. An axon’s path towards a target neuron is steered by growth cones in the tip of the axon that receive cues about the best path to follow from chemical attractants and repellents secreted by cells in the nervous system.

Tessier-Lavigne and his colleagues at the University of California, San Francisco, had previously identified a key attractant protein called netrin-1. Netrin-1 exerts its influence on growth cones by plugging into a receptor called DCC that nestles in the cell membrane. Conversely, a repellent protein called Slit triggers axons to grow away from a site by plugging into a receptor called Robo. Thus, a growing axon is attracted by netrin to a target way station in the spinal cord and then repelled from it toward the next way station by Sli

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3 4

Related biology news :

1. Growing pains: T. Rex was teenage giant
2. Growing new breed of vaccine-producing plants to fight human diseases worldwide
3. Growing replacement teeth and dental tissues
4. Growing human organs on the farm
5. Growing human antibodies in algae
6. Growing Up On Their Own: Smart Plastics Organize Themselves Into Useful Optical Devices
7. Colorado State University Study Reveals Climate Change, Longer Growing Seasons Could Harm Grazing On Western Shortgrass Steppe
8. DNA Helps Track Origins Of Growing Blight Problem
9. Introduction of the Rett protein in post-mitotic neurons rescues Rett Syndrome in mice
10. New study may explain how fats damage neurons in Alzheimers patients
11. Healthy neighbors rescue degenerating motor neurons

Post Your Comments:

(Date:8/26/2020)... ... August 25, 2020 , ... ... mitochondria, in partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology ... VISTA-2 study of SkQ1 ophthalmic solution in patients with moderate to severe ...
(Date:8/26/2020)... ... ... Modality Solutions, a biopharmaceutical cold chain validation engineering firm, is ... is the most prestigious ranking of the nation’s fastest-growing private companies. Modality Solutions made ... three-year revenue growth of 71 percent. , The Inc. 5000 list represents a ...
(Date:8/21/2020)... ... August 18, 2020 , ... Sentien Biotechnologies, Inc., ... the U.S. Food and Drug Administration (FDA) has approved the company’s Investigational New ... treatment of severe COVID-19. Approval of this IND allows Sentien to initiate a ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified ... systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , ... one or two switches in a push-pull configuration; yielding fast fall time for ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... software for the life sciences industry, today announced the release of its ... specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... ... July 17, 2020 , ... ... firm for the life sciences and food industries, is pleased to announce that ... Clinical Research – Business Development. , Charles is an accomplished and results-driven sales ...
(Date:7/7/2020)... (PRWEB) , ... July 06, 2020 , ... R3 International ... program featuring up to 200 million stem cells. Depending on the patient's condition, treatment ... in the US will die having some form of Alzheimers dementia, and the incidence ...
Breaking Biology Technology:
Cached News: