Growth Factor Stimulation Leads To Increase In New Neurons In The Striatum And Cortex Of The Brain

NEW ORLEANS -- The number of new neurons in the striatum and cortex, key areas of the brain responsible for movement, vision and higher mental functions, can be increased in adult rats through stimulation with a growth factor, Emory University and Regeneron Pharmaceuticals, Inc. researchers report at this week's Society for Neuroscience meeting.

The researchers administered the brain-derived neutrotrophic growth factor (BDNF) to the right lateral ventricle of the brains of adult rats. Not only did they confirm their previous findings that the number of neurons was increased in the olfactory bulb of the brain, but also that the number of neurons in the striatum and outer brain, or cortex, increased significantly.

Contrary to a long-held belief that neurons cannot reproduce themselves, Marla Luskin, Ph.D., associate professor of cell biology at Emory University School of Medicine, and colleague Tanja Zigova previously demonstrated that the adult mammalian forebrain has a remarkable capacity to produce new neurons. They identified and isolated a population of virtually pure neuronal cells - cells that have the capacity to produce more neurons - in the anterior part of the brain?s subventricular zone (SVZa).

This population was unlike all other cell populations in the developing brain which contain a mixture of progenitor cells for neurons and glial cells. Dr. Luskin demonstrated that this region actively produces new neurons both in vivo and in tissue culture. These newly generated neurons were found to travel to the olfactory bulb in the forebrain. In recent work they were able to significantly increase neuronal production in the olfactory bulb of the SVZa by administering BDNF in the ventricles of adult rats.

In their latest work, the researchers have demonstrated that after BDNF is administered, neuronal production also increases in the proliferative layer of the subventricular zone (S

Contact: Sarah Goodwin
Emory University Health Sciences Center

Page: 1 2

Related biology news :

1. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
2. Growth study of wild chimpanzees challenges assumptions about early humans
3. Growth hormone activates gene involved in healing damaged tissue
4. Growth factor shows promise in Parkinsons patients
5. Growth hormone could make farm fish bigger, faster to market
6. Growth hormone may stimulate production of T cells to boost bodys ability to fight HIV
7. Growth hormone may boost production of disease-fighting cells in elderly
8. Growth factor receptor signaling critical to intestinal tumor development, studies show
9. Growth factor may determine who grows new blood vessels that protect against heart attacks
10. Growth hormone involved in diabetic kidney disease, study finds
11. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: