HOME >> BIOLOGY >> NEWS
Growth Factors Improve Muscle Healing In Animals

Several growth factors speed the healing of muscle injuries in animal models, according to a report at this year's Orthopaedic Research Society meeting in Anaheim, Calif., by a research team from the University of Pittsburgh's Musculoskeletal Research Center and the Growth and Development Laboratory at Children's Hospital of Pittsburgh. This work paves the way for these compounds to be used one day in people with similar injuries, according to investigators there.

"Specific growth factors we used not only improved muscle regeneration; they quickened healing. These results open new horizons for the treatment of all types of muscle injuries," noted Johnny Huard, Ph.D., principal investigator on the study, assistant professor of orthopaedic surgery and of molecular genetics and biochemistry at the University of Pittsburgh and director of the Growth and Development Laboratory.

Muscle healing after an injury often is slow and incomplete because dense scar tissue forms at the site of an injury. "By injecting growth factors into a patient's muscle right after it suffers an injury, we might be able to stimulate the growth of functional muscle fibers, rather than see scar tissue develop. In this way, patients could expect to regain more muscle use than if they were simply treated with immobilization, rest or range of motion exercises," added Dr. Huard.

Many people suffer costly and disabling muscle injuries. For athletes, muscle injuries may end their careers because they cannot compete the same as before injury.

In their experiments, the investigators created an injury in both gastrocnemius (calf) muscles of 42 mice. The mice were then divided into three sets of 14 apiece. Each set received a different growth factor, either insulin growth factor type (IGF-1), basic fibroblast growth factor (b-FGF) or nerve growth factor (NGF). One gastrocnemius muscle in each mouse served as a control, receiving an injection of fluid alone.

After one month
'"/>

Contact: Lauren Ward
wardle@msx.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
2-Feb-1999


Page: 1 2

Related biology news :

1. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
2. Growth study of wild chimpanzees challenges assumptions about early humans
3. Growth hormone activates gene involved in healing damaged tissue
4. Growth factor shows promise in Parkinsons patients
5. Growth hormone could make farm fish bigger, faster to market
6. Growth hormone may stimulate production of T cells to boost bodys ability to fight HIV
7. Growth hormone may boost production of disease-fighting cells in elderly
8. Growth factor receptor signaling critical to intestinal tumor development, studies show
9. Growth factor may determine who grows new blood vessels that protect against heart attacks
10. Growth hormone involved in diabetic kidney disease, study finds
11. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/30/2019)... ... September 30, 2019 , ... Foresight Institute, a ... other transformative technologies, announced the winners for the 2019 Foresight Institute Feynman Prizes. ... Theory in nanotechnology/molecular manufacturing. , Established in 1993 and named in honor of ...
(Date:9/30/2019)... DURHAM, N.C. (PRWEB) , ... September 30, 2019 , ... ... therapy and an accepted model for studying the development and diseases of the human ... or potential activities of the progeny heart muscle cells to be clearly and easily ...
(Date:9/30/2019)... ALTO, Calif. (PRWEB) , ... ... ... Institute, a leading think tank, research, and public interest organization focused on ... prestigious Distinguished Student Prize. , The Award recognizes the College graduate or ...
Breaking Biology News(10 mins):
(Date:9/30/2019)... ... September 30, 2019 , ... The September 2019 ... Corporation , is now available online on the company’s global website. The Bridge ... X-ray diffraction, fluorescence and imaging, and presents articles, scientific papers and news reports. ...
(Date:9/24/2019)... POWAY, Calif. (PRWEB) , ... September 24, 2019 ... ... human adipose-derived stem cell company, has completed training and site qualification for clinical ... the process of recruitment and screening of potential clinical trial participants. , Clinical ...
(Date:9/17/2019)... SOMERSET, N.J. (PRWEB) , ... September 17, 2019 ... ... today announced that Julie Delaney, Director, Project and Clinical Supplies Management, Asia Pacific ... at the One Farrer Hotel, Singapore, on Sept. 25-26, 2019. , On Thursday, ...
(Date:9/17/2019)... ... 2019 , ... When a lot of researchers think of Visikol, they think ... characterization of tissues through the use of confocal and light sheet microscopy. However, over ... cell culture focused contract research organization and today offers 3D tissue imaging ...
Breaking Biology Technology:
Cached News: