HOME >> BIOLOGY >> NEWS
Growth Factors Improve Muscle Healing In Animals

Several growth factors speed the healing of muscle injuries in animal models, according to a report at this year's Orthopaedic Research Society meeting in Anaheim, Calif., by a research team from the University of Pittsburgh's Musculoskeletal Research Center and the Growth and Development Laboratory at Children's Hospital of Pittsburgh. This work paves the way for these compounds to be used one day in people with similar injuries, according to investigators there.

"Specific growth factors we used not only improved muscle regeneration; they quickened healing. These results open new horizons for the treatment of all types of muscle injuries," noted Johnny Huard, Ph.D., principal investigator on the study, assistant professor of orthopaedic surgery and of molecular genetics and biochemistry at the University of Pittsburgh and director of the Growth and Development Laboratory.

Muscle healing after an injury often is slow and incomplete because dense scar tissue forms at the site of an injury. "By injecting growth factors into a patient's muscle right after it suffers an injury, we might be able to stimulate the growth of functional muscle fibers, rather than see scar tissue develop. In this way, patients could expect to regain more muscle use than if they were simply treated with immobilization, rest or range of motion exercises," added Dr. Huard.

Many people suffer costly and disabling muscle injuries. For athletes, muscle injuries may end their careers because they cannot compete the same as before injury.

In their experiments, the investigators created an injury in both gastrocnemius (calf) muscles of 42 mice. The mice were then divided into three sets of 14 apiece. Each set received a different growth factor, either insulin growth factor type (IGF-1), basic fibroblast growth factor (b-FGF) or nerve growth factor (NGF). One gastrocnemius muscle in each mouse served as a control, receiving an injection of fluid alone.

After one month
'"/>

Contact: Lauren Ward
wardle@msx.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
2-Feb-1999


Page: 1 2

Related biology news :

1. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
2. Growth study of wild chimpanzees challenges assumptions about early humans
3. Growth hormone activates gene involved in healing damaged tissue
4. Growth factor shows promise in Parkinsons patients
5. Growth hormone could make farm fish bigger, faster to market
6. Growth hormone may stimulate production of T cells to boost bodys ability to fight HIV
7. Growth hormone may boost production of disease-fighting cells in elderly
8. Growth factor receptor signaling critical to intestinal tumor development, studies show
9. Growth factor may determine who grows new blood vessels that protect against heart attacks
10. Growth hormone involved in diabetic kidney disease, study finds
11. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: