HOME >> BIOLOGY >> NEWS
Growth Factors Improve Muscle Healing In Animals

Several growth factors speed the healing of muscle injuries in animal models, according to a report at this year's Orthopaedic Research Society meeting in Anaheim, Calif., by a research team from the University of Pittsburgh's Musculoskeletal Research Center and the Growth and Development Laboratory at Children's Hospital of Pittsburgh. This work paves the way for these compounds to be used one day in people with similar injuries, according to investigators there.

"Specific growth factors we used not only improved muscle regeneration; they quickened healing. These results open new horizons for the treatment of all types of muscle injuries," noted Johnny Huard, Ph.D., principal investigator on the study, assistant professor of orthopaedic surgery and of molecular genetics and biochemistry at the University of Pittsburgh and director of the Growth and Development Laboratory.

Muscle healing after an injury often is slow and incomplete because dense scar tissue forms at the site of an injury. "By injecting growth factors into a patient's muscle right after it suffers an injury, we might be able to stimulate the growth of functional muscle fibers, rather than see scar tissue develop. In this way, patients could expect to regain more muscle use than if they were simply treated with immobilization, rest or range of motion exercises," added Dr. Huard.

Many people suffer costly and disabling muscle injuries. For athletes, muscle injuries may end their careers because they cannot compete the same as before injury.

In their experiments, the investigators created an injury in both gastrocnemius (calf) muscles of 42 mice. The mice were then divided into three sets of 14 apiece. Each set received a different growth factor, either insulin growth factor type (IGF-1), basic fibroblast growth factor (b-FGF) or nerve growth factor (NGF). One gastrocnemius muscle in each mouse served as a control, receiving an injection of fluid alone.

After one month
'"/>

Contact: Lauren Ward
wardle@msx.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
2-Feb-1999


Page: 1 2

Related biology news :

1. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
2. Growth study of wild chimpanzees challenges assumptions about early humans
3. Growth hormone activates gene involved in healing damaged tissue
4. Growth factor shows promise in Parkinsons patients
5. Growth hormone could make farm fish bigger, faster to market
6. Growth hormone may stimulate production of T cells to boost bodys ability to fight HIV
7. Growth hormone may boost production of disease-fighting cells in elderly
8. Growth factor receptor signaling critical to intestinal tumor development, studies show
9. Growth factor may determine who grows new blood vessels that protect against heart attacks
10. Growth hormone involved in diabetic kidney disease, study finds
11. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Growth Factors Improve Muscle Healing Animals

(Date:10/19/2014)... India over the last 30 years contributed only ... during that time, according to a new study ... ., "Energy access is fundamental to development: it ... education, communication, and health," says IIASA researcher Shonali ... energy access is widely agreed to be an ...
(Date:10/17/2014)... in German . ... day in order to reproduce? And why are there two ... the latest issue of the research journal Molecular Human ... Steven Ramm from Bielefeld University Bielefeld has compiled this special ... for a female to copulate with several males in quick ...
(Date:10/16/2014)... and Washington land managers have a new synthesis of ... moist mixed-conifer (MMC) forests in the two states. ... in Eastern Oregon and Washington: A Synthesis of the ... a general technical report published by the U.S. Forest ... to a request from managers for a synthesis of ...
Breaking Biology News(10 mins):Improved electricity access has little impact on climate change 2Sperm wars 2New report synthesizes best available science on management of moist mixed-conifer forests 2
(Date:10/19/2014)... OCTOBER 20-22, 2014: The 9th Annual ... take place at the Congress Center Basel, ... now available at http://www.abim.ch . ... from all over the globe will exchange ... products and developments on the world market. ...
(Date:10/19/2014)... October 19, 2014 The Asia-Pacific ... market in Asia-Pacific with analysis and forecast of ... Asia Pacific Bromine Market report, to get an ... provides a glimpse of the segmentation in the ... tables and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asia-Pacific ... Analytics market in Asia-Pacific with analysis and forecast of ... million in 2014 to $208 million by 2019, at ... 2014 to 2019. , Browse through the TOC of ... idea of the in-depth analysis provided. It also provides ...
(Date:10/19/2014)... Asian Orthopedic braces and support systems report defines and segments ... revenue. The Orthopedic braces and support systems market in Asia ... at a developing CAGR of 4.4% from 2013 to 2018. ... and support systems market, to get an idea of the ... segmentation of orthopedic braces and support systems market in the ...
Breaking Biology Technology:The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4
Cached News: