Growth factor may determine who grows new blood vessels that protect against heart attacks

ateral-vessel growth. These variables include age, gender, high blood pressure, high blood cholesterol levels, smoking, diabetes and prior efforts to increase the blood flow in the heart, through bypass surgery or balloon angioplasty.

"We are now working out the molecular mechanisms that will allow for the development of a drug that would increase VEGF production in those patients who produce low levels of it and allow them to grow their own collateral blood vessels," says the study's senior author Andrew P. Levy, M.D., Ph.D., of the Rappaport Faculty of Medicine of Technion-Israel Institute of Technology.

The team has already developed a simple laboratory test to identify whether a person produces small or large amounts of VEGF when the heart cells get insufficient oxygen.

Coronary collateral vessels were once thought to pre-exist in the heart and open only to allow blood to flow through them when needed. However, scientists have learned in recent decades that the collateral beds are actually new vessels that grow in the areas of the heart that are deprived of life-sustaining oxygen because of reduced blood flow.

The study findings shed new light on the formation of collateral beds and suggest that certain heart patients might benefit from treatments that enhance their ability to grow new blood vessels. One approach might be gene therapy or a treatment that involves giving people who produce low levels of VEGF a genetically engineered version of the growth factor, according to the researchers.

If further research confirms the study's findings, physicians could easily identify patients unlikely to grow collateral arteries on their own. Such people would be expected to do poorly with currently available medical therapies and be the most likely to benefit from gene therapy or growth factor therapy, says Levy.

"This would allow us to develop oral medications that will enable individuals who produce low levels of VEGF during hypoxia to respon

Contact: Carole Bullock
American Heart Association

Page: 1 2 3

Related biology news :

1. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
2. Growth study of wild chimpanzees challenges assumptions about early humans
3. Growth hormone activates gene involved in healing damaged tissue
4. Growth factor shows promise in Parkinsons patients
5. Growth hormone could make farm fish bigger, faster to market
6. Growth hormone may stimulate production of T cells to boost bodys ability to fight HIV
7. Growth hormone may boost production of disease-fighting cells in elderly
8. Growth factor receptor signaling critical to intestinal tumor development, studies show
9. Growth hormone involved in diabetic kidney disease, study finds
10. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent
11. UC Berkeley Conference On Population Growth And The Environment

Post Your Comments:

(Date:9/17/2019)... CITY (PRWEB) , ... September 17, 2019 , ... ... and a group of doctors, scientists and engineers from the Medical University of ... the results of their work to-date in creating a neuroprosthetic system as part ...
(Date:9/14/2019)... , ... September 13, 2019 , ... ... imaging Society (WMIS) focused on non-invasive real-time tracking of gene therapy and advances ... of five years (and most cases fatal) lysomal storage diseases (LSD) are among ...
(Date:9/8/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... first human umbilical cord (hUC) MSC paired cell and media system designed ...
Breaking Biology News(10 mins):
(Date:10/10/2019)... (PRWEB) , ... October 09, 2019 , ... ... 10th, groups of Montgomery County middle school and high school students have improved ... stressors, utilize relaxation techniques and physical fitness, and apply lifelong social/interpersonal, leadership, problem-solving ...
(Date:10/10/2019)... Ariz. (PRWEB) , ... October 10, 2019 , ... ... Pratia , the largest network of clinical research centers in Europe. All Pratia ... site network in Europe to become trained and certified as Virtual Trial Capable ...
(Date:10/8/2019)... ... October 07, 2019 , ... Erchonia Corporation, the global leader ... announces that the U.S. Food and Drug Administration (FDA) has granted the company ... relief of chronic neck and shoulder pain of musculoskeletal origin. , Erchonia continues ...
(Date:10/3/2019)... , ... October 01, 2019 , ... ... relax and reset itself, announced the midway point of its randomized research trial ... the study is to measure the efficacy of a non-invasive technology which compares ...
Breaking Biology Technology:
Cached News: