HOME >> BIOLOGY >> NEWS
Growth factor receptor signaling critical to intestinal tumor development, studies show

CHAPEL HILL Scientists at the University of North Carolina at Chapel Hill and Vanderbilt University say they have uncovered a major clue to what causes and promotes development of intestinal tumors.

Working with laboratory mice, the researchers found that a molecule called epidermal growth factor receptor (Egfr) is necessary for most intestinal tumors to form. Their work also suggests that a drug or genetic manipulation that inhibits the receptors chemical signaling machinery should help treat advanced colorectal cancers in humans one day.

A report on the findings appears online today (Jan. 29) in the latest edition of the Proceedings of the National Academy of Sciences. Authors include doctoral student Reade B. Roberts and Dr. David W. Threadgill, assistant professor of genetics, both at the UNC School of Medicines Lineberger Comprehensive Cancer Center, and Dr. Robert J. Coffey, a cell biologist at Vanderbilt.

This Egfr receptor is very important to all kinds of tissues and organs, but there hasnt been any genetic proof in whole animals that it could affect a major cancer like colon cancer, Reade said. We think this work represents proof because it relied on genetic experiments that were highly controlled compared with just injecting mice with drugs and hoping that they would affect the receptor.

At UNC, the researchers studied two kinds of mice. They engineered one set to include a mutation called Apc-Min, which produces both human and mouse intestinal cancers, and another mutation known as waved 2, in which the Egfr was partially impaired. The other mice, litter mates of the first group, bore the same Apc-Min mutation, but also had normal Egfr genes.

Within three months, the first group developed 90 percent fewer intestinal polyps than the second, which showed that Egfr signaling was critical to intestinal tumor formation, scientists found. Some of the first group developed no tumors at all.

Surprisingly the size
'"/>

Contact: David Williamson
david_williamson@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
29-Jan-2002


Page: 1 2

Related biology news :

1. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
2. Growth study of wild chimpanzees challenges assumptions about early humans
3. Growth hormone activates gene involved in healing damaged tissue
4. Growth factor shows promise in Parkinsons patients
5. Growth hormone could make farm fish bigger, faster to market
6. Growth hormone may stimulate production of T cells to boost bodys ability to fight HIV
7. Growth hormone may boost production of disease-fighting cells in elderly
8. Growth factor may determine who grows new blood vessels that protect against heart attacks
9. Growth hormone involved in diabetic kidney disease, study finds
10. Report: High Carbon Dioxide Boosts Duke Forest Growth By 25 Percent
11. UC Berkeley Conference On Population Growth And The Environment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... ... solutions for drugs, biologics, cell and gene therapies, and consumer health products, today ... PEGS Boston Virtual Conference & Expo, taking place between Aug. 31 – September ...
(Date:8/21/2020)... ... August 19, 2020 , ... “How can we ... dedicated to Salivary Bioscience for more than twenty years. Together with Douglas Granger, ... " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and Steven ...
(Date:8/12/2020)... , ... August 12, 2020 , ... ... monitoring systems that are ideal for public health agencies of all sizes. With ... diseases and helping at-risk individuals find appropriate health care, Mosio helps public health ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... ... (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical ... team led by Dr MA has been using the zebrafish model to investigate ...
(Date:7/7/2020)... ... 2020 , ... Bio-IT World has announced the winners of ... University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were ... outstanding examples of how technology innovations and strategic initiatives can be powerful forces ...
(Date:7/1/2020)... , ... June 30, 2020 ... ... tissue data insights, today announced that the launch of a new ... with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. (“Lumeda”), ... announced the company has entered a license agreement with Roswell Park Comprehensive Cancer ... exclusive rights to Roswell Park intellectual property surrounding a novel medical device and ...
Breaking Biology Technology:
Cached News: