HIV Discriminates Amongst Cells

Researchers at Johns Hopkins have discovered that the human immunodeficiency virus (HIV) depends on the moving parts of a cell's surface in order to enter the cell. "The white blood cell has an intricate semi-rigid structural framework that is both pliable and mobile. It can assemble and disassemble rapidly in response to internal and external signals. This allows the cell to migrate across blood vessel walls and squeeze through small spaces," said David H. Schwartz, MD, PhD, associate professor, Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, who co-authored the paper with Sujatha Iyengar, PhD, research associate, and James E.K. Hildreth, MD, PhD, associate professor, Hopkins School of Medicine. Their study appeared in the current issue of the Journal of Virology.

The implications could be significant. "The clustering transmits signals to the cell that could be important for HIV replication," said Dr. Iyengar. She said that the findings could be relevant to many other kinds of viruses that use specific cell receptors. "A requirement for contracting actin in the target cell could also be a mechanism that prevents HIV from entering inactive cells, or cells in the early stages of cell death. We know that these are poor host cells for viral replication, and they don't have an active actin filament network to pull surface molecules together," Dr. Schwartz added. Dr. Hildreth and his colleagues cautioned that speculations about the role of receptor signaling in virus replication and the selective advantage to HIV of entering cells with intact actin remain unproven at this time. However, these roles are being tested.

Actin, a protein also used in muscles, is organized in a lattice just under the surface of the cell. Many protein molecules on the surface of the cell have tails that pass through the cell membrane and project into the cell. Through additional connecting proteins, ac

Contact: Lisbeth Pettengill
Johns Hopkins University Bloomberg School of Public Health

Page: 1 2

Related biology news :

1. Insurance Industry Discriminates Unfairly On Basis Of Genetic Information
2. Cells may shoot messenger to halt protein production
3. Cells from adult bone marrow can be converted into brain stem cells for transplantation
4. Cells ability to open bloods floodgates hinges on unexpected factors
5. Cells ability to live without oxygen give clues for treating major diseases
6. Cells use patch to heal tears, avoid destruction and disease
7. Food for thought: Cells dine on their own brains to stay fit and trim
8. Cells in patients noses hold potential to restore function in spinal cord injury
9. Cells on the verge of suicide
10. Cells from human umbilical cord blood help rats recover from stroke faster, new study finds
11. Researchers Propose A Revolutionary New Theory About The Way Cells Communicate

Post Your Comments:

(Date:4/16/2019)... ... April 16, 2019 , ... ... speakers for two signature events: The 2019 ISPE Biopharmaceutical Manufacturing Conference , ... 20–21 June. Taking place in one of the most influential bio hubs, Boston, ...
(Date:4/9/2019)... ... ... The McLeod Center for Cancer Treatment and Research has been ... conducted by an independent, third-party panel of experts in radiation oncology, patient safety and ... McLeod is the only such cancer center in South Carolina. The hospital also represents ...
(Date:4/4/2019)... ALISO VIEJO, Calif. (PRWEB) , ... April 02, ... ... a leading clinical genetics testing company, will present results demonstrating that RNA genetic ... hereditary cancer genetic testing. This study, awarded as a Top Rated poster, is ...
Breaking Biology News(10 mins):
(Date:3/15/2019)... and ATLANTA (PRWEB) , ... ... ... the acquisition of 100% equity in American Process Inc. and affiliate companies ... the Alpena Biorefinery in Alpena Michigan, the Thomaston Biorefinery and R&D center ...
(Date:3/14/2019)... ... ... The growth in the number and complexity of regulations as well as ... intelligence (RI) systems are not keeping with ... and cheaper. With a diversity of information sources, identifying and analyzing context based intelligence ...
(Date:3/14/2019)... , ... March 14, 2019 , ... ... release announcing that its Canadian partner, the Eye Machine Canada Inc., had been ... Oculus’s pioneering technology for treating Age-Related Macular Degeneration (AMD). , The previous month, ...
(Date:3/14/2019)... (PRWEB) , ... March 13, 2019 , ... ... its 2019 ISPE Europe Biotechnology Conference , taking place in Brussels, Belgium ... biotechnology best practices, technical and operational solutions, and innovative approaches. , “Biopharmaceuticals ...
Breaking Biology Technology:
Cached News: