HIV Infected Adults In UCSF Study Show Evidence Of Thymus Activity

Contrary to the widely held belief that the thymus -- an organ essential for producing competent immune cells -- is not functional in adulthood, researchers at the Gladstone Institute of Virology and Immunology have shown that half of the HIV-infected patients in a recent study appear to have substantial thymus function.

Thymus function in HIV-infected patients may mean that their bodies can compensate for the loss of T cells caused by HIV by re-awakening a dormant thymus and producing healthy T cells to fight off HIV infection. It also raises the possibility of therapies to replenish the immune system, by thymus stimulation or transplant, for those without a working thymus.

"Given the evidence that HIV can infect and destroy the thymus, this is an outcome that is not predicted by textbooks or clinical experience," said Joseph M. McCune, MD, PhD, associate professor of medicine at UC San Francisco, and an associate investigator at the UCSF-affiliated Gladstone Institute of Virology and Immunology, located at San Francisco General Hospital. McCune, who is the lead investigator of the study, said, "It is surprising not only that abundant thymic tissue could be found in these patients, but also that the percentage showing such tissue was so high."

"For patients over 40, it's a clear black and white difference, since in every uninfected individual over 40 that we looked at, we never saw thymus," he said. "Yet among those over 40 infected with HIV, five out of the ten had abundant thymus tissue."

Among the 99 HIV-positive patients in that study, the size of the thymus corresponded to the number of T cells circulating in the patient's blood, regardless of age: a larger thymus meant more T cells. All but one of the patients under 40 who were in the early stages of HIV disease progression had abundant thymic tissue, indicating that the thymus might be triggered into action by the first losses of T cells.

The research findings are reported in the June 1

Contact: Mitzy Baker
(415) 476-3804
University of California - San Francisco

Page: 1 2 3

Related biology news :

1. Study: Infected people need not carry AIDS virus long before passing it on
2. Experimental Therapy Makes HIV-Infected Cells Commit Suicide
3. Pool Of Latently Infected, "Resting" Cells Established Early In HIV Infection
4. The Perils Of Discontinuing Therapy: Without HAART, Cytokines Stimulate HIV From Latently Infected Cells
5. Scientists Say Latently Infected Cells May Stoke the Fire of HIV Replication
6. Jefferson Scientists Devise Way To Treat Animals Chronically Infected With Hepatitis B
7. Short-Course TB Prophylaxis Effective In HIV-Infected Individuals
8. Study: Adults maintain significant improvement in ADHD with long-term use of amphetamine
9. Study Indicates Adolescent Smokers Are More Susceptible To Long-Term DNA Damage From Smoking Than Adults Smokers
10. Adults Need To Increase Intake Of Folate; Some Women Should Take More
11. Trees, Grass Foster Childrens Play And Encourage Adults To Supervise

Post Your Comments:

(Date:7/1/2020)... ... 2020 , ... Catalent, a global leader in clinical supply ... facility in Minakuchi, located in the Shiga prefecture of Japan. , Operating in ... new 60,000-square-foot facility will provide customers with flexible clinical supply solutions, serving both ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC , ... that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ) ... with severe COVID-19. This is the first study of an XPO1 inhibitor in ...
(Date:6/23/2020)... THE WOODLNDS, Texas (PRWEB) , ... June 23, ... ... in X-ray analytical instrumentation, is pleased to announce the next event in a ... of X-ray scattering. , The TOPIQ series of webinars was developed in response ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... August 29, 2020 , ... ... Nutrition manufacturing capability in Wuxi, China. The new plant operation will provide the ... and advanced technology. , “This facility will improve the flexibility of our ...
(Date:8/12/2020)... ... August 11, 2020 , ... Modality ... for free its new white paper – Simulated Transport Methodologies. Regulatory expectations ... biologics licensing application (BLA). In response, Modality Solutions shares an explanation of ...
(Date:8/3/2020)... ... ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions its ... MediVet Biologics since its formation in 2016, the company is relaunching itself under the ... on its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet ... to three different materials for use with CRM, neurostimulation, vascular, and related devices. ... to meet specific design requirements, performance, and cost criteria; especially where solid wire ...
Breaking Biology Technology:
Cached News: