HOME >> BIOLOGY >> NEWS
HIV exhausts the immune system through chronic non-specific activation

Like most persistent viruses, HIV uses a variety of strategies to counteract its host's response to infection. HIV infects the very cells that coordinate the immune response, which compromises the immune system and leaves the body susceptible to normally harmless microorganisms. It is these opportunistic infections, rather than the virus itself, that make HIV so deadly. Victor Appay and colleagues now show that an important effect of persistent HIV infection is generally elevated immune activation. Rather than being beneficial to the host, this causes non-specific premature maturation of many of the remaining functional T-cells. The resulting premature aging and exhaustion of the immune system increase the likelihood of opportunistic infection.

HIV targets white blood cells with surface receptors called CD4. These CD4, or helper, T-cells normally orchestrate the body's immune response. In response to a particular pathogen, they induce cytotoxic T-cells (or CD8 T-cells) and other immune cells to multiply and differentiate--that is, to become specially equipped to recognize and target a particular pathogen, or antigen. When the researchers analyzed T-cells from a group of untreated HIV infected individuals at different stages--acute infection, chronic infection without progression, and chronic infection with signs of progression--they found to their surprise that during acute HIV infection, the vast majority (80%90%) of the overall CD8 T-cell population was activated--not just the HIV-specific CD8 T-cells. CD8 T-cells specific to two other chronic (and usually benign) pathogens, EpsteinBarr virus and cytomegalovirus, showed significant activation levels during HIV acute infection. And as HIV/AIDS progresses, many of the CD8 T-cells developed to a state of senescence where they are no longer active.

These results show that chronic and nonspecific overactivation of the immune system during HIV infection produces a large pool of highly differentiated T-c
'"/>

Contact: Barbara Cohen
bcohen@plos.org
415-624-1206
Public Library of Science
17-Feb-2004


Page: 1 2

Related biology news :

1. Long-term effects of carbon monoxide poisoning are an autoimmune reaction
2. Probing the surface of white blood cells to enhance immune system medicine
3. Researchers uncover secrets of immune systems munitions factory
4. Regular physical activity really does boost immune system in older men
5. New model can aid in understanding immune system diseases
6. New mechanism for display of foreign proteins to immune system
7. Babies with DiGeorge syndrome saved by immune supression, thymus transplant
8. Researchers develop better understanding of immune response to viral infection
9. Patients cells from tumors, the immune system merged for customized cancer therapy
10. Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys
11. Lack of immune system protein prevents lupus-like condition in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... Va. (PRWEB) , ... July 08, 2020 , ... ... Latest on Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, ... need a comparability study, but what is the most effective way to complete ...
(Date:7/1/2020)... N.J. (PRWEB) , ... July 01, 2020 , ... ... announced that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in ... the company’s existing Japanese clinical supply facility located in Kakegawa, the new 60,000-square-foot ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... services, today announced that the company has received ISO9001:2015 certification for the ... and research industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, a highly ... closed on the purchase of greenfield for a new, expanded manufacturing facility. The ... 21 acres in the initial acquisition, with an option to purchase an additional ...
(Date:7/31/2020)... Texas (PRWEB) , ... July 29, 2020 , ... ... solutions today announced the launch of its new tagline, “BUILDING FOR LIFE.” The ... biopharmaceutical industry and around the globe, requiring fast track capacity to provide patients ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and ... it did not take off as quickly as people initially expected, and where eSource ... capturing data electronically for clinical trials and then repurposing it for downstream analysis, at ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and ... a great surgery is only the beginning of a successful study, while protecting and ... Join Brad Gien, Global Head of Surgery from Envigo in a ...
Breaking Biology Technology:
Cached News: