HOME >> BIOLOGY >> NEWS
HIV exhausts the immune system through chronic non-specific activation

Like most persistent viruses, HIV uses a variety of strategies to counteract its host's response to infection. HIV infects the very cells that coordinate the immune response, which compromises the immune system and leaves the body susceptible to normally harmless microorganisms. It is these opportunistic infections, rather than the virus itself, that make HIV so deadly. Victor Appay and colleagues now show that an important effect of persistent HIV infection is generally elevated immune activation. Rather than being beneficial to the host, this causes non-specific premature maturation of many of the remaining functional T-cells. The resulting premature aging and exhaustion of the immune system increase the likelihood of opportunistic infection.

HIV targets white blood cells with surface receptors called CD4. These CD4, or helper, T-cells normally orchestrate the body's immune response. In response to a particular pathogen, they induce cytotoxic T-cells (or CD8 T-cells) and other immune cells to multiply and differentiate--that is, to become specially equipped to recognize and target a particular pathogen, or antigen. When the researchers analyzed T-cells from a group of untreated HIV infected individuals at different stages--acute infection, chronic infection without progression, and chronic infection with signs of progression--they found to their surprise that during acute HIV infection, the vast majority (80%90%) of the overall CD8 T-cell population was activated--not just the HIV-specific CD8 T-cells. CD8 T-cells specific to two other chronic (and usually benign) pathogens, EpsteinBarr virus and cytomegalovirus, showed significant activation levels during HIV acute infection. And as HIV/AIDS progresses, many of the CD8 T-cells developed to a state of senescence where they are no longer active.

These results show that chronic and nonspecific overactivation of the immune system during HIV infection produces a large pool of highly differentiated T-c
'"/>

Contact: Barbara Cohen
bcohen@plos.org
415-624-1206
Public Library of Science
17-Feb-2004


Page: 1 2

Related biology news :

1. Long-term effects of carbon monoxide poisoning are an autoimmune reaction
2. Probing the surface of white blood cells to enhance immune system medicine
3. Researchers uncover secrets of immune systems munitions factory
4. Regular physical activity really does boost immune system in older men
5. New model can aid in understanding immune system diseases
6. New mechanism for display of foreign proteins to immune system
7. Babies with DiGeorge syndrome saved by immune supression, thymus transplant
8. Researchers develop better understanding of immune response to viral infection
9. Patients cells from tumors, the immune system merged for customized cancer therapy
10. Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys
11. Lack of immune system protein prevents lupus-like condition in mice

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access ... 15.1% over the next decade to reach approximately $1,580 million by ... and forecasts for all the given segments on global as well ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... ... accelerate pharmaceutical and biotherapeutics development, announces the launch of the new NHS ... to gain kinetic binding data for a wide range of molecules, including small ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... The ... time on Immuno-Oncology 360° (IO360°) programming through a series of upcoming panels and events. ... February 7-9, 2018, at The Roosevelt Hotel in New York City. , “With our ...
(Date:8/14/2017)... Portland, Oregon (PRWEB) , ... August 14, 2017 ... ... modules that provide essential device-to-computer interconnect using USB or PCI Express, announced the ... hardware. , SYZYGY is intended to satisfy the need for a compact, low ...
(Date:8/11/2017)... ... ... Algenist continues to disrupt the skincare industry with today’s debut of GENIUS Liquid ... the key structural element skin needs to maintain its youthful appearance and Algenist is ... First to market with proprietary collagen water active , Active ...
Breaking Biology Technology:
Cached News: