HOME >> BIOLOGY >> NEWS
Handling stress: life and death decisions at the cellular level

The daily life of a cell can be inordinately stressful. Two papers in the September 15th issue of Genes & Development highlight recent discoveries that have been made regarding how cells handle environmental stress, and decide whether or not their life is worth living. Both papers lend valuable insight into the ways that different cells respond to oxygen deprivation, or hypoxia.

Teetering on the Edge

A team of scientists led by Dr. Bohdan Wasylyk at the INSERM research center in France has discovered that the steroid receptor, GR, and the tumor suppressor, p53, interact during periods of oxygen deprivation to help balance the decision between cell survival and cell death.

p53 is commonly referred to as "the guardian of the genome" for its integral role in mediating either cell cycle arrest or cell death in response to various types of cell stress. Loss of p53 function can lead to unregulated cell proliferation, an event that is associated with the development of most tumors. The glucocorticoid receptor, GR, binds steroid hormones and helps to mediate the normal response to stress.

Dr. Wasylyk and colleagues determined that under hypoxic conditions p53 and ligand-bound GR directly associate with one another in the cytoplasm of the cell. This p53/GR complex is then bound by another protein, Hdm2, which facilitates the degredation of both p53 and GR. In this manner, the p53-mediated death response is held in check by GR, and the GR-mediated survival response is held in check by p53. This antagonistic interaction between p53 and GR represents a novel mechanism to balance cell survival and cell death in response to environmental stress.

Nervous Stress

Scientists from UMASS Medical School and Yale University School of Medicine report on the involvement of a key player in the stress response pathway in neurons. The JIP1 protein is a component of a pathway that is activated in response to ce
'"/>

Contact: Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory
14-Sep-2001


Page: 1 2

Related biology news :

1. Key cell-death step found
2. Optimizing proteins death domain halts leukemia in laboratory study
3. Small, Smac-like molecule encourages death of cancer cells
4. Heartless worms hold clues to cardiac arrhythmias, sudden death
5. Ecologists help keep death off the roads
6. Researchers identify gene for a primary form of sudden infant death sydrome (SIDS)
7. Cell death protein has surprising role in cell migration
8. Improved nutrition could prevent more than half of the worlds child deaths annually
9. JGI, VBI help unravel sudden oak death & soybean disease
10. Virginia Bioinformatics Institute researcher advances fight against sudden oak death disease
11. Cell growth and death controlled by single pathway in lymphoma cancer model

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... BioCatch , the global leader in behavioral biometrics, reported a ... over 40 granted and pending patents. ... , The Company,s IP portfolio expansion ... Device, and Method Estimating Force Applied to a Touch Surface, " ... components needed to estimate the force and pressure applied to touch surfaces ...
(Date:12/6/2016)... 6, 2016  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... offering of €500.0 million principal amount of its 1.414% senior ... its 2.425% senior unsecured notes due 2026. ... December 13, 2016, subject to the satisfaction of customary closing conditions.  ... The Company intends to use the ...
(Date:12/5/2016)... 5, 2016  The Office of Justice Programs, ... CT Scans Enhance or Replace Medico Legal Autopsies?" ... supporting or replacing forensic autopsies with postmortem X-ray ... In response to recommendations made by The ... CT scans as a potential component of medicolegal ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... SAN DIEGO , Dec. 8, 2016 /PRNewswire-USNewswire/ ... treatments for congestive heart failure and type 2 ... license for a novel adeno-associated virus (AAV) vector ... Kay , M.D., Ph.D., at Stanford University. The ... of its paracrine gene therapy product pipeline. ...
(Date:12/8/2016)... Oxford Gene Technology (OGT), The Molecular ... with the launch of the SureSeq myPanel™ NGS Custom FH ... familial hypercholesterolemia (FH). The panel delivers single nucleotide variation (SNV) ... panel and allows customisation by ,mix and match, of fully-optimised ... LDLR , P C SK9 , ...
(Date:12/8/2016)... ... 08, 2016 , ... This CAST literature review and report looks at problems ... on the economic effects in countries that are major global commodity exporters and importers, ... resultant risk of low level presence (LLP) puts large volumes of trade worth billions ...
(Date:12/8/2016)... Dec. 8, 2016 Eutilex Co. Ltd. today ... (US $18.9M) Series A financing. This financing round included ... Venture and SNU Bio Angel. This new funding brings ... KRW (US $27.7M) since its founding in 2015. ... the development and commercialization of its immuno-oncology programs, expand ...
Breaking Biology Technology:
Cached News: