HOME >> BIOLOGY >> NEWS
Handling stress: life and death decisions at the cellular level

The daily life of a cell can be inordinately stressful. Two papers in the September 15th issue of Genes & Development highlight recent discoveries that have been made regarding how cells handle environmental stress, and decide whether or not their life is worth living. Both papers lend valuable insight into the ways that different cells respond to oxygen deprivation, or hypoxia.

Teetering on the Edge

A team of scientists led by Dr. Bohdan Wasylyk at the INSERM research center in France has discovered that the steroid receptor, GR, and the tumor suppressor, p53, interact during periods of oxygen deprivation to help balance the decision between cell survival and cell death.

p53 is commonly referred to as "the guardian of the genome" for its integral role in mediating either cell cycle arrest or cell death in response to various types of cell stress. Loss of p53 function can lead to unregulated cell proliferation, an event that is associated with the development of most tumors. The glucocorticoid receptor, GR, binds steroid hormones and helps to mediate the normal response to stress.

Dr. Wasylyk and colleagues determined that under hypoxic conditions p53 and ligand-bound GR directly associate with one another in the cytoplasm of the cell. This p53/GR complex is then bound by another protein, Hdm2, which facilitates the degredation of both p53 and GR. In this manner, the p53-mediated death response is held in check by GR, and the GR-mediated survival response is held in check by p53. This antagonistic interaction between p53 and GR represents a novel mechanism to balance cell survival and cell death in response to environmental stress.

Nervous Stress

Scientists from UMASS Medical School and Yale University School of Medicine report on the involvement of a key player in the stress response pathway in neurons. The JIP1 protein is a component of a pathway that is activated in response to ce
'"/>

Contact: Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory
14-Sep-2001


Page: 1 2

Related biology news :

1. Key cell-death step found
2. Optimizing proteins death domain halts leukemia in laboratory study
3. Small, Smac-like molecule encourages death of cancer cells
4. Heartless worms hold clues to cardiac arrhythmias, sudden death
5. Ecologists help keep death off the roads
6. Researchers identify gene for a primary form of sudden infant death sydrome (SIDS)
7. Cell death protein has surprising role in cell migration
8. Improved nutrition could prevent more than half of the worlds child deaths annually
9. JGI, VBI help unravel sudden oak death & soybean disease
10. Virginia Bioinformatics Institute researcher advances fight against sudden oak death disease
11. Cell growth and death controlled by single pathway in lymphoma cancer model

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
(Date:5/20/2016)... 2016  VoiceIt is excited to announce its ... By working together, VoiceIt and VoicePass will ... VoicePass take slightly different approaches to voice biometrics, ... and usability. ... partnership. "This marketing and technology partnership ...
(Date:4/28/2016)... FRANCISCO and BANGALORE, India , ... of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... provider, today announced a global partnership that will ... way to use mobile banking and payment services. ... is a key innovation area for financial services, but it ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... ... 23, 2016 , ... Supplyframe, the Industry Network for electronics ... Lab . Located in Pasadena, Calif., the Design Lab’s mission is to bring ... designed, built and brought to market. , The Design Lab is Supplyframe’s physical ...
(Date:6/23/2016)... Andrew D Zelenetz ... Published recently in Oncology ... touchONCOLOGY, Andrew D Zelenetz , discusses the ... is placing an increasing burden on healthcare systems ... With the patents on many biologics expiring, interest ...
Breaking Biology Technology:
Cached News: