HOME >> BIOLOGY >> NEWS
Handling stress: life and death decisions at the cellular level

The daily life of a cell can be inordinately stressful. Two papers in the September 15th issue of Genes & Development highlight recent discoveries that have been made regarding how cells handle environmental stress, and decide whether or not their life is worth living. Both papers lend valuable insight into the ways that different cells respond to oxygen deprivation, or hypoxia.

Teetering on the Edge

A team of scientists led by Dr. Bohdan Wasylyk at the INSERM research center in France has discovered that the steroid receptor, GR, and the tumor suppressor, p53, interact during periods of oxygen deprivation to help balance the decision between cell survival and cell death.

p53 is commonly referred to as "the guardian of the genome" for its integral role in mediating either cell cycle arrest or cell death in response to various types of cell stress. Loss of p53 function can lead to unregulated cell proliferation, an event that is associated with the development of most tumors. The glucocorticoid receptor, GR, binds steroid hormones and helps to mediate the normal response to stress.

Dr. Wasylyk and colleagues determined that under hypoxic conditions p53 and ligand-bound GR directly associate with one another in the cytoplasm of the cell. This p53/GR complex is then bound by another protein, Hdm2, which facilitates the degredation of both p53 and GR. In this manner, the p53-mediated death response is held in check by GR, and the GR-mediated survival response is held in check by p53. This antagonistic interaction between p53 and GR represents a novel mechanism to balance cell survival and cell death in response to environmental stress.

Nervous Stress

Scientists from UMASS Medical School and Yale University School of Medicine report on the involvement of a key player in the stress response pathway in neurons. The JIP1 protein is a component of a pathway that is activated in response to ce
'"/>

Contact: Nora Poppito
poppito@cshl.org
Cold Spring Harbor Laboratory
14-Sep-2001


Page: 1 2

Related biology news :

1. Key cell-death step found
2. Optimizing proteins death domain halts leukemia in laboratory study
3. Small, Smac-like molecule encourages death of cancer cells
4. Heartless worms hold clues to cardiac arrhythmias, sudden death
5. Ecologists help keep death off the roads
6. Researchers identify gene for a primary form of sudden infant death sydrome (SIDS)
7. Cell death protein has surprising role in cell migration
8. Improved nutrition could prevent more than half of the worlds child deaths annually
9. JGI, VBI help unravel sudden oak death & soybean disease
10. Virginia Bioinformatics Institute researcher advances fight against sudden oak death disease
11. Cell growth and death controlled by single pathway in lymphoma cancer model

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Handling stress life and death decisions the cellular level

(Date:12/17/2014)... 15, 2014  HITLAB SM announced today its completion ... its adherence to current U.S. Food and Drug Administration ... smart device and smart phone application trials utilizing the ... "HITLAB is determined to improve global healthcare access, ...
(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel experience and ... Over the past decade, ePassports, biometric readers, and secure ... through border control via eGates and Automated Passport Control ... and land borders across the globe. ...
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in India 2015-2019" ... major trend emerging in this market is the adoption ... than one characteristic of an individual for verification and ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
(Date:1/23/2015)... Portal Solutions , a technology consulting ... Microsoft Office 365 and SharePoint platforms , today announces its ... being one of the region’s fastest-growing mid-sized companies based on ... , “To be recognized a second year in a row ...
(Date:1/22/2015)... GEA Niro Soavi the leader in ... the PandaPLUS 2000, which is ideal for new applications ... cell disruption . This compact laboratory homogenizer is the ... food, food additives and ingredients as well as for ...
(Date:1/22/2015)... Johnston, RI (PRWEB) January 22, 2015 ... State , The growing team of brand-neutral, independent consultants, ... CIO Philip Rogers explained that over the years, his ... including , Moroso, Town of Plainfield, as well as ...
(Date:1/22/2015)... 22, 2015 Dr. Greg Leyer of UAS ... Scripps Natural Supplements Pre-Conference seminar on probiotics in San Diego, ... annual continuing education conference for health care professionals. This year’s ... topic of probiotics in health. Dr. Leyer spoke about the ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2
Cached News: