'HapMap' scientists provide detailed plans

Northern and Western European ancestry living in Utah. While the Nigerian and U.S. samples will be from 30 "trios" -- sets of parents and an adult child -- 45 samples from Japanese and 45 samples from Han Chinese will be from unrelated people.

Chakravarti, who plans to use the freely available products of the HapMap to determine the genetic underpinnings of heart disease, diabetes and psychiatric illness, received funds from the NIH last year to participate in the international project as one of two computer analysis centers in the United States. The other analysis group is at the Center for Genome Research at the Whitehead Institute in Cambridge, Mass.

"Analyzing the sequence information from all these samples is going to require new mathematical and computing methods," says Chakravarti. "So while the sequences and genotypes are being figured out, we are hard at work developing new ways to analyze the data so we can be confident in the map we end up creating. Anything less isn't enough."

Chakravarti, David Cutler, Carl Kashuk and Peter Chen of the McKusick-Nathans Institute are co-authors of the report, along with the many other members of the International HapMap Consortium. Chakravarti and Hopkins geneticist David Valle were members of the initial National Institutes of Health planning group on Populations and Ethical, Legal and Social Issues. The Johns Hopkins HapMap effort is funded by the National Institutes of Health.


Contact: Joanna Downer
Johns Hopkins Medical Institutions

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