HOME >> BIOLOGY >> NEWS
Harbor Branch Oceanographic Institution And Novartis Pharma AG Sign AgreementFor Licensing And Development Of Anti-Cancer Compound, Discodermolide

FT. PIERCE, FL- Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida, has entered into an agreement to license its marine-derived, anti-cancer agent, discodermolide, to Novartis Pharma AG, Basle, Switzerland, on an exclusive world-wide basis.

Discodermolide is an anti-cancer compound derived from the marine sponge, Discodermia dissoluta, first collected in 1987 by Dr. Shirley A. Pomponi, Director of Harbor Branch's Division of Biomedical Marine Research. The compound was isolated from the sponge and characterized by Dr. Sarath P. Gunasekera and Dr. Ross E. Longley at Harbor Branch in 1990. Subsequent studies by the Harbor Branch team and collaborators revealed the compound to be a potent, anti-tumor agent that is effective in killing human cancer cells in vitro with a mechanism of action similar to that of the clinical anti-cancer agent Taxol .

Under terms of the license agreement, Harbor Branch grants Novartis exclusive, world-wide rights for the development, use, manufacture and sale of discodermolide for all potential therapeutic indications. Novartis will provide Harbor Branch with funding for continued research on discodermolide, as well as future payments based on developmental milestones and royalties from the sale of the compound as a drug for the treatment of cancer.

J. Seward Johnson, Jr., of Princeton, N.J., Chairman of Harbor Branch, states: "This agreement is the result of over 14 years of drug discovery research at Harbor Branch, and is the culmination of the last 8 years of research on discodermolide by the Harbor Branch team. Given the exciting and promising pre-clinical data on discodermolide and the expertise in drug development which Novartis provides, our hope is that discodermolide will eventually surpass other chemotherapeutic agents as an effective treatment for cancer".

Harbor Branch Oceanographic Institution, Inc. is one of the nation's premi
'"/>

Contact: Shirley A. Pomponi, Ph.D.
dbmr@hboi.edu
(561) 465-2400 X449
Harbor Branch Oceanographic Institution
16-Apr-1998


Page: 1 2

Related biology news :

1. Academy Harbor Consortium releases letter on mercury to President Bush
2. Microorganisms are cleaning up Boston Harbor, UMass study finds
3. 2002 Cold Spring Harbor Laboratory Meetings
4. Harbor Branch scientist aids in Mexico manatee rescue effort
5. Harbor Branch scientists to study predation habits of jellyfish-like animals in Gulf Of Maine
6. Harbor Branch to receive $2.1 million of a $4.9 million multi-institutional grant to discover new natural product leads for cancer chemotherapy
7. Harbor Branch Scientists Discover Bioluminescent Octopus
8. Harbor Branch Web Developers Team With ABC News To Bring Ocean Adventure To A Computer Near You
9. Harbor Branch Web Developers Bring Adventures @Sea To Every Desktop
10. Harbor Branch Oceanographic Trains Displaced Fishermen And Women In New Careers As Aquafarmers
11. Harbor Branch Oceanographic Institutions Aquaculture Division Studies Viability Of Controlled Reproduction Of Southern Flounder In Captivity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/9/2016)... 9, 2016 Paris Police ... video security solution to ensure the safety of people and ... during the major tournament Teleste, an international technology ... services, announced today that its video security solution will be ... back up public safety across the country. The system roll-out ...
(Date:6/2/2016)... June 2, 2016 The Department of ... awarded the 44 million US Dollar project, for the ... Plates including Personalization, Enrolment, and IT Infrastructure , ... the production and implementation of Identity Management Solutions. Numerous renowned ... Decatur was selected for the most ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" ... by its major shareholders, Clean Technology Fund I, LP ... States based venture capital funds which together ... (on a fully diluted, as converted basis), that they ... their entire equity holdings in Biorem to TUS Holdings ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the ... today the Clinical Reach Virtual Patient Encounter CONSULT module which enables both ... physician and clinical trial team. , Using the CONSULT module, patients and physicians can ...
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... , June 24, 2016 Epic ... sensitively detects cancers susceptible to PARP inhibitors by ... tumor cells (CTCs). The new test has already ... therapeutics in multiple cancer types. Over ... DNA damage response pathways, including PARP, ATM, ATR, ...
Breaking Biology Technology:
Cached News: