HOME >> BIOLOGY >> NEWS
Harvard and Alexion researchers report successful transplantation of immuneprotected neurons in primate model of Parkinson's disease

MIAMI BEACH, FL, Oct. 25, 1999 -- Researchers from the Harvard Medical School and Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN) today reported that the transplantation of immunoprotected pig neurons into non-human primate models of Parkinson's disease resulted in successful engraftment and function of the transplanted cells. Presented here at the 29th Meeting of the Society for Neuroscience, the study shows that the acceptance of the engrafted cells was enhanced through the use of Alexion's proprietary C5 Complement Inhibitor. 5G1.1, an anti-inflammatory C5 Inhibitor drug, is currently being tested in Phase II clinical trials for the treatment of various chronic inflammatory disorders.

Entitled "Xenotransplantation of Transgenic Fetal Pig Dopamine Neurons Into Monkey with Complement Inhibition," the report comes from the laboratories of Dr. Ole Isacson of the Neuroregeneration Laboratories, Harvard Medical School, McLean Hospital, in Belmont, MA, working in collaboration with scientists from Alexion Pharmaceuticals, Inc., New Haven, CT.

Parkinson's disease is a progressive disorder of the central nervous system affecting over one million people in the United States. Clinically, the disease is characterized by a decrease in spontaneous movements, rigidity and tremor. Parkinson's disease is caused by the degeneration of the dopamine-producing neurons in the substantia nigra of the brain, resulting in decreased dopamine availability.

In the study, these scientists demonstrated that transplantation of neurons from Alexion's transgenic pigs restored dopamine production locally and selectively in the affected part of the brain in primates with Parkinson's-like disease. Additionally, the results show that the activity of Alexion's pharmaceutical C5 Inhibitor further improved the survival of the immunoprotected neurons.

"The combined use of Alexion's dual immunoprotective technologies now offers hope for a significant improvement in the survival of
'"/>

Contact: Tom Baker
t.baker@noonanrusso.com
212-696-4455 ext 205
Noonan/Russo Communications
24-Oct-1999


Page: 1 2 3 4

Related biology news :

1. Harvard Stem Cell Institute hosts inaugural symposia
2. Harvard Medical School launches new department to study human biology at the level of whole systems
3. Harvard Medical School consortium receives grant to harness microbe genomes for environment/energy
4. UCSF-Harvard team publishes major HIV therapy study over objections of sponsor; compound shows no effect on slowing disease progression
5. Harvard Medical School researchers discover first in a new class of mitosis inhibitors
6. Harvard expert speaks on lead toxicity to chemists meeting in New Orleans
7. Harvard Medical School Researchers Identify Four Human Genes Essential To Cell Division; Discovery Yields New Target For Cancer Therapies
8. Harvard Medical School Researchers Present Atomic Structure Of DNA-Replicating Enzyme Widely Used In DNA Sequencing
9. Harvard, Duke Researchers Discover Off-switch Inside Human Cells
10. Alexion and Yale discover harmful complement activation in patients with acute coronary syndrome
11. Yale and Alexion report advance in spinal cord repair

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... , March 21, 2017   Neurotechnology , ... recognition technologies, today announced the release of the ... which provides improved facial recognition using up to ... a single computer. The new version uses deep ... accuracy, and it utilizes a Graphing Processing Unit ...
(Date:3/16/2017)... 2017 CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made ... ... Used combined in one project, multi-biometric solutions provide a crucial contribution against identity ... Used combined in one project, multi-biometric ... ...
(Date:3/7/2017)... CITY , March 7, 2017   HireVue ... help top global companies identify the best talent, faster, ... as Chief Sales Officer (CSO) and Diana Kucer ... appointments round out a seasoned executive team poised to drive ... beyond, building on a year of record bookings in ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... monitoring solutions, today announced the hire of Dr. Sigmund “Sig” Floyd as Vice ... applications, strategic partnerships and joint development activities. , “Dr. Floyd’s career has spanned ...
(Date:3/22/2017)... , March 22, 2017 Good Start ... it has eclipsed the 130 million covered lives mark ... Shield of Texas . With newly ... Company continues to enjoy strong payor acceptance based on ... clinical programs and genetic counseling, its industry-leading customer care ...
(Date:3/22/2017)... 22, 2017 /PRNewswire/ - FACIT announced a seed ... "Propellon"), a start-up created by FACIT focused on ... investment, combined with non-dilutive capital, achieves a targeted ... funding enables Propellon to accelerate the nomination of ... financing and/or entering a strategic partnership for clinical ...
(Date:3/22/2017)... ... March 21, 2017 , ... Proper ... information on the desired increase and/or decrease in antibody-dependent cellular cytotoxicity or complement-dependent ... profiling of therapeutic antibodies. , To meet this demand, the team at ...
Breaking Biology Technology:
Cached News: