HOME >> BIOLOGY >> NEWS
Healing the brain from the inside out

Researchers find existing brain cells -- not transplants -- may replenish dead counterparts

Boston, MA -- June 22, 2000 -- Healing a human brain from the inside out was supposed to be impossible. The evolutionary choice for mammals was believed to be between a brain that was fixable and a brain that was too complex to tinker with after it was formed, especially from the inside. Now comes the discovery from a Children's Hospital research group, published today in the journal Nature, that our brain's nerve cells or neurons could one day be induced into healing themselves.

The paper from Jeffrey Macklis, Harvard Medical School associate professor of neurology at Children's Hospital, and his associates Sanjay Magavi and Blair Leavitt, flies in the face of a century of neuroscience conviction that in mammals the brain and particularly the cerebral cortex is incapable of healing itselfa dogma that a series of recent experiments has shaken.

"Somewhere during evolution it was believed," Macklis says, "our brain, unlike the brains of other lower vertebrates, decided it would no longer do self-repair. The assumption has been that because we as mammals build a very complex brain, we don't want to mess around with it. We know now that this view isn't correct."

The Macklis group was able to induce stem cells deep in the cerebral cortex of adult mice to replace damaged neurons. These new neurons grew from already present immature precursor cells into fully formed, connected, and mature replacements. These home grown neurons demonstrate for the first time that the brain can heal itself from the inside out, without transplantation.

This breakthrough in fundamental neural cell biology is a long way from clinical application but Macklis says that if the mechanisms at work here can be understood and controlled, it may open a new avenue someday for treatment of degenerative brain diseases and central nervous system injuries.

Until recently
'"/>

Contact: John Lacey
john_lacey@hms.harvard.edu
617-432-0441
Harvard Medical School
20-Jun-2000


Page: 1 2 3

Related biology news :

1. Healing power in a gene
2. Healing the waters: a holistic native American Indian approach
3. Healing the waters: A holistic Native American Indian approach
4. UCSF Researchers Identify Key Genes In Bone Healing Process That Could Lead To New, Molecular-Based Treatments
5. Growth Factors Improve Muscle Healing In Animals
6. Improved Oxygen Bath To Heal Wounds, Lessen Number Of Amputations: Sandia To Sign Agreement With Numotech To Help Create Home-Use Healing Facility
7. Engineering Our Arteries: Replacements And Assisted Healing
8. Trial shows which brain cancer patients benefit from temozolomide
9. Targeted therapy knocks out pediatric brain cancer in mice
10. New way to protect brain from stroke damage
11. Chemical signals health of brain cells Symposium

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... to expand at a CAGR of 25.76% during the ... is the primary factor for the growth of the ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem ... technology, application, and geography. The stem cell market of ...
(Date:3/30/2017)... 30, 2017 Trends, opportunities and forecast in ... by technology (fingerprint, AFIS, iris recognition, facial recognition, hand ... by end use industry (government and law enforcement, commercial ... banking, and others), and by region ( North ... Asia Pacific , and the Rest of ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , ... October 10, 2017 ... ... cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing ... HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
(Date:10/9/2017)... ... 09, 2017 , ... The Giving Tree Wellness Center announces ... needs of consumers who are incorporating medical marijuana into their wellness and health ... As operators of two successful Valley dispensaries, The Giving Tree’s two founders, Lilach ...
(Date:10/6/2017)... , ... October 06, 2017 , ... ... within the healthcare and technology sector at their fourth annual Conference where founders, ... 30 inspiring speakers and the ELEVATE pitch competition showcasing early stage digital health ...
Breaking Biology Technology:
Cached News: