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Heart Disease Symptoms Worsen When Body Tries To Adapt

ring at Hopkins. "The data support the hypothesis that although genetic mutations can have primary effects, chronic responses to these mutations may be equally important in the progression of disease.

"Continuing studies will need to determine the exact nature of these adaptations and the extent to which inhibiting the responses can modify disease progression. These insights may help us design new therapies."

More than half of hypertrophic cardiomyopathy cases are hereditary. The disease affects about one in 1,000 people, causing shortness of breath, dizziness, fainting and chest pain. It is often treated by medications such as beta-blockers or calcium channel blockers.

The study's other authors were Dmitrios Georgakopoulos of Hopkins; Michael E. Christe, Michael Giewat and J.G. Seidman of Howard Hughes Medical Institute; and Christine M. Seidman of Brigham and Women's Hospital.


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Contact: Karen Infeld
kinfeld@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
4-Mar-1999


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