HOME >> BIOLOGY >> NEWS
Heart attack in a laboratory dish

NWO researchers at Utrecht University have given heart muscle cells a heart attack in the laboratory. This allowed them to observe clearly the change that takes place in the cell membrane during an attack and how the change sometimes leads to the death of the cell.

In a healthy cell, one of the components of the membrane, the phospholipids, are asymmetrically distributed across the two layers of the surrounding shell. During a (simulated) heart attack, however, and immediately after it, this asymmetrical distribution is partly lost. The researchers discovered that the absolute number of lipids increased in the outer layer of the membrane because they moved from the inner to the outer layer. This imbalance in phospholipid content probably plays a major role in the damage to the heart muscle cell and its death. It is possible that the quantity of calcium has something to do with changes in the original asymmetry, given that during a heart attack, the concentration of calcium ions in the heart muscle cell increases. The calcium ions can in turn produce the changes in the distribution of lipids.

Besides the blockage, the research team also studied the second phase of a heart attack, reperfusion, when the blood flow is restored. If this happens quickly enough, the tissue can be saved, but otherwise the asymmetrical distribution of the cell membrane phospholipids is lost and the imbalance in phospholipid content becomes more pronounced. Reactive oxygen causes damage to the fatty acid tails of the lipids. If it takes too long for the blood flow to be restored, or if it fails to do so at all, the muscle cell dies and scar tissue is formed.

The results of the research, financed by NWO, clarify why the heart muscle cells are damaged during a heart attack, but they do not yet make it possible to develop a treatment for the problem. This will require further research into just what happens in the lipids.


'"/>

Contact: Michel Philippens
news@nwo.nl
31-70-344-0784
Netherlands Organization for Scientific Research
7-May-2001


Page: 1

Related biology news :

1. Heart gene yields insights into evolution, disease risk
2. Heartless worms hold clues to cardiac arrhythmias, sudden death
3. Media invited to attend International Society For Heart & Lung Transplantation meeting April 21-24
4. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
5. Heart may heal with help from oxygen-sensitive genes, new study suggests
6. Heart drug might help fight chronic fungal infections
7. Heart disease among some Japanese may be due to sequencing variation inside a gene
8. Heart size and function uncoupled by researchers
9. Heart disease gene linked to prostate cancer
10. Heart-felt stress can be more dangerous to immune system
11. Society for Womens Health Research will be releasing reports related to Heart Month

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2019)... , ... April 30, 2019 , ... ... LLP is pleased to announce that Gunes Bender, Ph.D., a registered patent ... sciences practice group. In his new role, Bender provides technical support and scientific ...
(Date:4/27/2019)... ... April 26, 2019 , ... Washington State University’s Center for ... than 30 student venture teams, representing nearly 150 students, presented their business ideas ... The top five teams in the College League were awarded prize money with ...
(Date:4/25/2019)... , ... April 24, 2019 , ... ... Services Secretary Alex Azar today, a broad collective of 62 individual scientists, bioethicists, ... American Society of Gene & Cell Therapy (ASGCT), across industry and academia called ...
Breaking Biology News(10 mins):
(Date:5/7/2019)... ... May 06, 2019 , ... "The new Liquid Nitrogen ... repositories being asked to store cellular products being used in adoptive therapy ... are world leaders, who have shared their expertise in building and managing facilities ...
(Date:5/4/2019)... ... 03, 2019 , ... Diopsys Inc, the world leader in ... vision test, a new full field electroretinography (ffERG) protocol designed to detect ... Americans will have glaucoma, with black Americans having the highest prevalence rate. This ...
(Date:5/2/2019)... S.D. (PRWEB) , ... April 30, 2019 , ... The ... from industrial scale macro breweries to local craft breweries, and even home brewing clubs ... very complex chemical and biological processes, that when mastered can produce a superb product. ...
(Date:5/2/2019)... (PRWEB) , ... May 02, 2019 , ... ... genetics testing company, will present results documenting discrepancies between U.S. insurer policies for ... for patients at risk for hereditary breast and ovarian cancer (HBOC). ...
Breaking Biology Technology:
Cached News: