HOME >> BIOLOGY >> NEWS
Heart attack in a laboratory dish

NWO researchers at Utrecht University have given heart muscle cells a heart attack in the laboratory. This allowed them to observe clearly the change that takes place in the cell membrane during an attack and how the change sometimes leads to the death of the cell.

In a healthy cell, one of the components of the membrane, the phospholipids, are asymmetrically distributed across the two layers of the surrounding shell. During a (simulated) heart attack, however, and immediately after it, this asymmetrical distribution is partly lost. The researchers discovered that the absolute number of lipids increased in the outer layer of the membrane because they moved from the inner to the outer layer. This imbalance in phospholipid content probably plays a major role in the damage to the heart muscle cell and its death. It is possible that the quantity of calcium has something to do with changes in the original asymmetry, given that during a heart attack, the concentration of calcium ions in the heart muscle cell increases. The calcium ions can in turn produce the changes in the distribution of lipids.

Besides the blockage, the research team also studied the second phase of a heart attack, reperfusion, when the blood flow is restored. If this happens quickly enough, the tissue can be saved, but otherwise the asymmetrical distribution of the cell membrane phospholipids is lost and the imbalance in phospholipid content becomes more pronounced. Reactive oxygen causes damage to the fatty acid tails of the lipids. If it takes too long for the blood flow to be restored, or if it fails to do so at all, the muscle cell dies and scar tissue is formed.

The results of the research, financed by NWO, clarify why the heart muscle cells are damaged during a heart attack, but they do not yet make it possible to develop a treatment for the problem. This will require further research into just what happens in the lipids.


'"/>

Contact: Michel Philippens
news@nwo.nl
31-70-344-0784
Netherlands Organization for Scientific Research
7-May-2001


Page: 1

Related biology news :

1. Heart gene yields insights into evolution, disease risk
2. Heartless worms hold clues to cardiac arrhythmias, sudden death
3. Media invited to attend International Society For Heart & Lung Transplantation meeting April 21-24
4. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
5. Heart may heal with help from oxygen-sensitive genes, new study suggests
6. Heart drug might help fight chronic fungal infections
7. Heart disease among some Japanese may be due to sequencing variation inside a gene
8. Heart size and function uncoupled by researchers
9. Heart disease gene linked to prostate cancer
10. Heart-felt stress can be more dangerous to immune system
11. Society for Womens Health Research will be releasing reports related to Heart Month

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/25/2018)... ... December 24, 2018 , ... Researchers at the Icahn ... new use for a long-standing computational concept known as “blacklisting,” which is commonly ... messages. Using blacklisting as a filter to single out genetic variations in patient ...
(Date:12/19/2018)... ... December 19, 2018 , ... InTouchMD’s flagship product, Pulse ... healthcare for 2018. , PM360 is featuring the recognition in its 7th annual ... services offered to the pharmaceutical and medical device industries. , “This recognition comes at ...
(Date:12/18/2018)... ... 18, 2018 , ... CP Merritt is a national champion Arabian horse that ... however in 2006, he had a medical setback that caused him to limp at ... from cartilage degeneration in his right rear fetlock. Such an injury could be ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... ... ... Leading authority on how to bridge the gap between online and offline ... How to Increase Sales with Proven Networking Strategies.” In honor of his ... of America (AFA). , Itzkowich is hosting “The Referral Playbook” signing event at ...
(Date:12/5/2018)... (PRWEB) , ... December 04, ... ... an established North American full-service contract research organization (CRO), announced the acquisition ... transaction significantly strengthens ARG’s reach and experience in the management of clinical ...
(Date:11/27/2018)... SPRINGS, Ga. (PRWEB) , ... November 27, 2018 , ... ... can now visit Dr. Dan Myers’ practice for treatment, with or without a referral. ... cosmetic procedures and tools, including porcelain veneers, dental implants, bridges and custom crowns. ...
(Date:11/20/2018)... ... November 19, 2018 , ... Patients with missing teeth ... dental implants from Dr. Dan Myers at THE DENTIST Centers without a referral. ... and restorations for the last 20 years. He now offers skilled dental care in ...
Breaking Biology Technology:
Cached News: