HOME >> BIOLOGY >> NEWS
Heart drug might help fight chronic fungal infections

Johns Hopkins scientists have determined why a drug routinely used to treat heart arrhythmias might become a crucial addition to fighting chronic fungal infections, they report online in the Journal of Biological Chemistry.

Last year, scientists elsewhere noted the drug's ability to kill fungi. Now, a Johns Hopkins research team has found that amiodarone kills by disrupting cells' interior and exterior calcium balance.

Importantly, this is completely different from the way in which commonly used antifungal agents miconazole and fluconazole stop fungal growth, say the researchers. In their experiments, a combination of amiodarone and either of the "azoles" killed dramatically more fungi than expected.

"This antiarrhythmic drug, in low doses, combined with azoles looks very promising in the lab and appears to be worth taking a look at clinically," says Rajini Rao, Ph.D., associate professor of physiology in the Johns Hopkins School of Medicine's Institute for Basic Biomedical Sciences. "The azoles prevent fungi from growing, but don't actually kill them -- the immune system is supposed to do that. Amiodarone kills them instead of keeping them dormant."

While fungal infections in general are easy to get rid of, in patients with depressed immune systems or with conditions like cystic fibrosis that increase susceptibility to chronic or recurring fungal infections, prolonged use of azoles can lead to the fungus becoming resistant to treatment. Finding a way to treat severe and life-threatening fungal infections with an option that boosts the effects of azoles without relying on the strength of the immune system is attractive, says Rao, who studies how calcium is brought into cells.

"Importantly, amiodarone and miconazole or fluconazole were synergistic, killing more fungus together than expected by just adding their individual results," says Rao. "What we've learned about amiodarone's effects on cellular calcium lev
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
5-Jun-2003


Page: 1 2

Related biology news :

1. Heart gene yields insights into evolution, disease risk
2. Heartless worms hold clues to cardiac arrhythmias, sudden death
3. Media invited to attend International Society For Heart & Lung Transplantation meeting April 21-24
4. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
5. Heart may heal with help from oxygen-sensitive genes, new study suggests
6. Heart disease among some Japanese may be due to sequencing variation inside a gene
7. Heart size and function uncoupled by researchers
8. Heart disease gene linked to prostate cancer
9. Heart-felt stress can be more dangerous to immune system
10. Society for Womens Health Research will be releasing reports related to Heart Month
11. Heart attack in a laboratory dish

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/18/2019)... (PRWEB) , ... March 18, 2019 , ... ... cost-effective, but also successfully leverages the patient perspective and improves participation by better ... is one way of involving the patient in the entire process from development ...
(Date:3/13/2019)... N.J. (PRWEB) , ... March 13, 2019 , ... ... for the Pharmaceutical, Biotechnology and Medical Device Industries, is excited to announce that it ... in early February 2019 and the newly installed and highly experienced management team ...
(Date:3/9/2019)... ... March 07, 2019 , ... A firm believer in causes ... & Lymphoma Society (LLS). This donation will help fund not only research to find ... families. , “We are always on the lookout for ways to make a ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... , ... March 19, 2019 , ... ... Inc. (Konica Minolta) today announced the formation of their inaugural Scientific Advisory Board. ... of precision medicine that takes into account individual variability in genes, environment, and ...
(Date:3/18/2019)... BARBARA, Calif. (PRWEB) , ... March 18, 2019 , ... ... have partnered together to develop solutions that allow life science companies to easily comply ... requirements. USDM’s Cloud Assurance ™ is a managed service delivering end-to-end GxP compliance ...
(Date:3/14/2019)... ... March 14, 2019 , ... Open ... themed “Navigating the Full Spectrum of Case Management,” continues as CMSA makes plans ... conference is the only case management industry conference serving the educational and networking ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... solution for preclinical research organizations. It is a low code, GDPR/21 CFR ... and facilities, innovative technology-driven automated data capture and seamless data and information ...
Breaking Biology Technology:
Cached News: