HOME >> BIOLOGY >> NEWS
Heart size and function uncoupled by researchers

t PI3K gamma, we had normal heart size and much better function. With both of these proteins shut down, we had huge hearts and much better function. When we took out PI3K alpha, the mice had tiny hearts but normal function, and when we took out both PTEN and PI3K alpha, the mice had tiny hearts and heart failure. With these genes we can determine heart size and can genetically control how well our hearts pump, irrespective of the heart being normal or enlarged."

According to the World Health Organization, cardiovascular disease will be the most common cause of death within 20 years. This research goes directly to helping alleviate this disease, the researchers say. Every patient with heart or cardiovascular disease goes through a stage of heart enlargement. Those with hypertension, for example, need their heart to pump and contract more; as a result, the heart muscle enlarges to compensate for the extra work. At a certain point, however, this compensation doesn't work anymore and the heart starts to fail.

The scientists hope that this research will form the basis for better treatments for people with chronic heart failure or cardiovascular disease. "The problem now is that there is no drug which maintains the pumping function of the heart," says Penninger. "We found the proteins that genetically control this. So the hope is that if you can shut down PI3K gamma, the heart will function much better after a heart attack or chronic heart failure, even if the patient has an enlarged heart."


'"/>

Contact: Janet Wong
jf.wong@utoronto.ca
416-978-5949
University of Toronto
19-Sep-2002


Page: 1 2

Related biology news :

1. Heart gene yields insights into evolution, disease risk
2. Heartless worms hold clues to cardiac arrhythmias, sudden death
3. Media invited to attend International Society For Heart & Lung Transplantation meeting April 21-24
4. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
5. Heart may heal with help from oxygen-sensitive genes, new study suggests
6. Heart drug might help fight chronic fungal infections
7. Heart disease among some Japanese may be due to sequencing variation inside a gene
8. Heart disease gene linked to prostate cancer
9. Heart-felt stress can be more dangerous to immune system
10. Society for Womens Health Research will be releasing reports related to Heart Month
11. Heart attack in a laboratory dish

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/23/2019)... ... , ... NanoFUSE is pleased to announce the ... spine and orthopedic use. Bioactive glass is a calcium phosphate coated silica that ... orthopedics for over 30 years and now NanoFUSE Biologics has used advanced research ...
(Date:7/19/2019)... ... July 19, 2019 , ... ... and Crystalline States – Insights from Synchrotron X-ray Pair Distribution (SXPDF) Studies”. The ... with Chris Benmore of Argonne National Laboratory and Gabriel de Araujo of the ...
(Date:7/17/2019)... Pa. (PRWEB) , ... July 15, 2019 , ... ... of computational science expertise exclusively for Life Sciences and Healthcare companies, announces the ... provide critical advisory services and strategic direction to start-up and emerging bio-pharma companies ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... Fla. (PRWEB) , ... June 10, 2019 , ... ... in science and technology in an upcoming episode, scheduled to broadcast 4Q/2019. Check ... the Eppendorf Group) and will educate viewers about how its technology facilitates laboratories ...
(Date:6/11/2019)... POWAY, Calif. (PRWEB) , ... June 11, 2019 ... ... parent company of Personalized Stem Cells Inc. (PSC) , has announced that ... of Public Health, Food and Drug Branch for manufacturing. This is an ...
(Date:5/31/2019)... ... May 29, 2019 , ... For many years, the primary forms of cancer ... breakthrough therapies. Advances in immuno-oncology have led to the advent of Chimeric Antigen Receptor ... T cell receptors known as “CARs”. The CAR enables the final product to produce ...
(Date:5/31/2019)... ... May 30, 2019 , ... Object ... announce the strategic acquisition of Metabiologics, Inc., a globally recognized leader in the ... ownership and commercialization rights to a full spectrum of botulinum neurotoxins, as well ...
Breaking Biology Technology:
Cached News: