HOME >> BIOLOGY >> NEWS
Heartless worms hold clues to cardiac arrhythmias, sudden death

Could help lead to development of drugs that don't cause calcium channel block

The worm C. elegans seems an unlikely candidate for studies related to cardiac arrhythmias. After all, the microscopic organism doesn't even have a heart.

That fact did not deter Christina I. Petersen, Ph.D., research assistant professor of Anesthesiology at Vanderbilt University Medical Center. Petersen and colleagues, including Jeffrey R. Balser, M.D., Ph.D., associate vice chancellor for Research at Vanderbilt, have now developed a C. elegans-based screening tool to identify novel protein regulators of a potassium channel involved in the rhythmic heartbeat.

They report the success of their approach in the Aug. 10 issue of the Proceedings of the National Academy of Sciences. The tool could lead to ways to prevent arrhythmias and sudden death associated with block of a potassium channel called HERG (Human ether-a-go-go related gene).

Many therapeutic drugs -- antihistamines, antidepressants, antibiotics -- block HERG, Petersen said. This undesired blockade can cause acquired long QT syndrome, a disorder that puts patients at risk for life-threatening arrhythmias. It is not clear why some individuals receiving a HERG-blocking drug develop the syndrome, Petersen said.

"It's a serious problem," she said. "The FDA now requires that every drug be assayed for HERG block before it is approved." Even medicines that might be beneficial for the vast majority of patients do not make it to the market or have been pulled from the market -- if they block HERG, Petersen said.

"The pharmaceutical industry is very interested in finding ways to screen for susceptibility to acquired long QT syndrome and in discovering how to prevent it."

Other investigators have demonstrated that variations in HERG itself do not account for the majority of interindividual differences. Petersen and colleagues suspected that other proteins -- modula
'"/>


19-Aug-2004


Page: 1 2 3 4

Related biology news :

1. Convulsions in worms mimic epileptic seizures
2. Whale carcass yields bone-devouring worms
3. Oxygen sensing in worms may hold key to healthy blood pressure in humans
4. Researchers discover how worms noses sense oxygen
5. Drunken worms reveal a genetic basis of alcohol response
6. Study in worms shows how genes linked to complexity in animals
7. Two worms are better than one
8. Cows resistance to worms is genetically determined
9. Alien earthworms changing ecology of Northeast forests
10. Amorous worms reveal effects of Chernobyl
11. Scientists study roundworms for behavior patterns

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/4/2019)... ... December 03, 2019 , ... ... technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer ... Ethicann Pharmaceuticals Inc. (“Ethicann”), a Calgary-based pharmaceutical company using botanically sourced cannabinoid ...
(Date:11/27/2019)... (PRWEB) , ... November 25, 2019 , ... Though the ... for the more than 55 million travelers expected to hit the roads and the ... application worth it’s weight in truffle oil will offer a simple design, mouth-watering pictures ...
(Date:11/22/2019)... N.Y. (PRWEB) , ... November 21, 2019 , ... ... developed at Roswell Park Comprehensive Cancer Center have announced a major step forward ... Michael Ciesielski, PhD, have announced that the company, spun off from Roswell Park ...
Breaking Biology News(10 mins):
(Date:12/18/2019)... , ... December 17, 2019 , ... ... its 31st FDA clearance for reprocessing Electrophysiology (EP) devices since the company’s inception ... Stryker Sustainability Solutions and SterilMed (a Johnson & Johnson company) have received 2 ...
(Date:12/18/2019)... ... 2019 , ... Tune in to CNBC on Saturday, December 28th at 11:00aET ... for more information on this program. , With a look at Avatar Partners ... system to increase the efficiency, safety and effectiveness of equipment, systems, and processes for ...
(Date:12/6/2019)... ... December 06, 2019 , ... ... has received FDA 510(k) clearance for its latest CAPERE® Thrombectomy System for ... suggests the CAPERE® offers great benefits for first-in-line treatment for nonsurgical removal ...
(Date:12/4/2019)... ... December 03, 2019 , ... Absolute Antibody ... a partnership with the Recombinant Antibody Network (RAN), a consortium of three expert ... (UCSF) with a common goal to generate recombinant antibodies at a proteome-wide scale. ...
Breaking Biology Technology:
Cached News: