HOME >> BIOLOGY >> NEWS
Heartless worms hold clues to cardiac arrhythmias, sudden death

ting factors -- are influencing HERG channel susceptibility to drug block.

That's where the worm came in. "This paper is really a proof of principle of the utility of using C. elegans to search for these HERG-interacting proteins," Petersen said.

Even though the worm doesn't have a heart, it does have a pharynx -- a muscular tube that "pumps" food inside. The pharynx, Petersen said, is similar in many ways to a heart. It has an intrinsic beating -- like a heartbeat -- that responds to neuronal input by speeding up or slowing down.

The investigators were able to take advantage of a worm line with a mutation in the worm version of HERG. The mutation, unc-103, causes profound neuromuscular defects, including a pharyngeal pumping defect that Petersen noticed as she learned to work with the worms.

"I remember the first time I saw it (the pumping defect)," she said. "It looked just like a cardiac arrhythmia." Whereas the normal worm pharynx has a rhythmic "beat" and rarely pauses, Petersen said, the unc-103 pharynx has long stretches of pauses, "as if the worms are having an arrhythmia."

The team developed a method to quantitate the pauses and demonstrated that "knocking out" the unc-103 protein using a technique called RNA interference restored normal pharyngeal pumping. The investigators reasoned that if they knocked out important HERG modulators, the effect would be the same: a restoration of rhythmic pharyngeal pumping.

To test this concept, they chose several candidate genes known to interact with HERG or other related potassium channels, knocked them out, and looked for improvements in the pumping defect. For two of the candidates, pumping improved -- the arrhythmia got better. One of these was a protein called KCR1, which Sabina Kupershmidt, Ph.D., assistant professor of Anesthesiology, and colleagues at Vanderbilt recently demonstrated prevents drug block of HERG in cardiac cells grown in the laboratory.
'"/>


19-Aug-2004


Page: 1 2 3 4

Related biology news :

1. Convulsions in worms mimic epileptic seizures
2. Whale carcass yields bone-devouring worms
3. Oxygen sensing in worms may hold key to healthy blood pressure in humans
4. Researchers discover how worms noses sense oxygen
5. Drunken worms reveal a genetic basis of alcohol response
6. Study in worms shows how genes linked to complexity in animals
7. Two worms are better than one
8. Cows resistance to worms is genetically determined
9. Alien earthworms changing ecology of Northeast forests
10. Amorous worms reveal effects of Chernobyl
11. Scientists study roundworms for behavior patterns

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... 2019 , ... KICVentures announced today its plans to host an ... Management-Driven ASC Conference in Chicago on Thursday, June 13th at 6:30 pm. The event ... in the 3rd floor Ticino Hospitality room in space #74T. , The event will ...
(Date:6/6/2019)... ... 05, 2019 , ... Pelican BioThermal , the global ... service center in Mexico City, Mexico. Mexico is the second largest pharmaceutical market ... $1.75 billion in pharmaceutical exports since 2015. The Mexico City network station will ...
(Date:6/4/2019)... ... June 04, 2019 , ... Most preclinical EEG ... seizure risk signals, usually based on variations of amplitude, frequency or spike train ... diagnostic methodology due to the complexity and variability of the signal, and automation ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... Ky. (PRWEB) , ... July 08, 2019 , ... ... Award winner. The company’s SmartLight Indicator was recognized as the 2019 Innovative Product ... sensors industry forward. The prestigious awards were during Sensors Expo & Conference ...
(Date:6/12/2019)... TOWNSHIP, N.J. (PRWEB) , ... June 12, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... with Shanghai Zillion has been signed. The agreement will grant exclusive rights for ...
(Date:6/11/2019)... Calif. (PRWEB) , ... June 11, 2019 , ... ... company of Personalized Stem Cells Inc. (PSC) , has announced that their ... Public Health, Food and Drug Branch for manufacturing. This is an important ...
(Date:5/31/2019)... ... 30, 2019 , ... World Compliance Seminars today announced a ... in Boston, MA. This peer recommended interactive workshop is always selected by professionals ... kick off with a compendial treatment of Data Integrity fundamentals. After laying the ...
Breaking Biology Technology:
Cached News: