HOME >> BIOLOGY >> NEWS
Heavy metal research is music to biologists' ears

Crab and lobster are more than perennial summer favorites--they are also a good dietary source of copper. Yes, the stuff of pennies is crucial for life--the metal copper is an important helper to many cellular enzymes, including superoxide dismutase (SOD), which sops up dangerous "free radicals" that accumulate inside cells. Defects in SOD have been linked to some inherited forms of amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.

In an important advance in understanding the molecular underpinnings of this disease, scientists supported by the National Institute of General Medical Sciences (NIGMS) have deciphered the three-dimensional structure of a yeast copper "chaperone" protein, a molecule that transports copper to the SOD enzyme. Although copper is necessary for life, it is a potentially toxic "heavy metal" that--in the wrong cellular locale--can damage other molecules, and in some cases can even cause disease. As the name suggests, the copper chaperone protein protects copper from unwanted cellular interactions and safely delivers it to its destination.

The work also identifies a potential target for developing drugs to treat Lou Gehrig's disease, a uniformly fatal condition.

The research report appears in the August 1999 issue of the journal Nature Structural Biology.

A little over six years ago, scientists first linked Lou Gehrig's disease to SOD by showing that some people with the disease had "misspellings" in the gene that encodes SOD. The finding prompted a series of studies aimed at determining how copper gets inserted into this prevalent cellular enzyme. In 1997, Dr. Valeria Culotta of The Johns Hopkins University, collaborating with Dr. Thomas O'Halloran of Northwestern University, first discovered a protein that ferries copper molecules throughout a yeast cell; they coined it a copper chaperone. (Further research has shown that the yeast chaperone is very similar to its counterpart in humans.) Around the s
'"/>

Contact: Alison Davis
davisa@nigms.nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
28-Jul-1999


Page: 1 2 3

Related biology news :

1. Heavy consumption of tainted fish curbs adult learning and memory
2. Old Sins Industrial Metabolism, Heavy Metal Pollution, and Environmental Transition in Central Europe
3. Engineered Bacteria Scavenge Heavy Metals
4. Dartmouth Medical School Researchers Discover Heavy Metal Contamination In Northern Mexico
5. Heavy Traffic At The Nuclear Pore: How Proteins And RNA Leave The Cell Nucleus
6. Ecological Farming May Cause More Heavy Metals In The Soil
7. PET Project Helps Reduce Pollution Threat From Heavy Metals
8. Purdue study finds antioxidant protects metal-eating plants
9. Innovative ceramic-on-metal hip replacements to undergo clinical trials
10. A new hope for heavy metal contaminated soils
11. UCSD biologists discover key step for designer plants that could clean up heavy metals

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Heavy metal research music biologists ears

(Date:10/18/2014)... suspected genetic conditions, a certain type of exome sequencing ... than traditional molecular diagnostic methods, according to a study ... released to coincide with the American Society of Human ... protein­coding region of the genome (the complete set of ... organism), has been rapidly applied in research settings and ...
(Date:10/16/2014)... Cancer constantly wages war on the human body. ... a stalemate. In pancreatic cancer, this stalemate—known as ... becoming aggressively malignant, a phenomena that is poorly ... in the laboratory of Salvatore Torquato, a Professor ... the conditions surrounding tumor dormancy and the switch ...
(Date:10/16/2014)... Syncytial Virus causes severe respiratory tract infections and ... year. Scientists at VIB and Ghent University have ... counteract this common virus infection. , Xavier ... that paves the way for the development of ... virus that causes suffering in numerous small children ...
Breaking Biology News(10 mins):Study examines type of exome sequencing and molecular diagnostic yield 2Study examines type of exome sequencing and molecular diagnostic yield 3Modeling tumor dormancy 2New perspectives for development of an RSV vaccine 2
(Date:10/20/2014)... Oct. 20, 2014 PureTech , a ... big healthcare problems, announced today the closing of ... participation from Invesco Perpetual, a $120 Billion group ... drive PureTech,s existing pipeline forward and to advance ... the scientific creativity to really go for the ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Latin ... the market in Latin America with analysis and forecast ... in 2013, and is expected to reach $2,366.8 million ... to 2018. , Browse through the TOC of the ... idea of the in-depth analysis provided. It also provides ...
(Date:10/19/2014)... The Asian Automatic patient billing report ... and forecast of revenue. The Automatic patient billing market ... million by 2018, at a developing CAGR of 7.2% ... of the Asian Automatic patient billing market, to get ... provides a glimpse of the segmentation of this market ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The ... Defense, & Homeland Security), Technology, Payload, Type & ... and segments the global unmanned ground vehicle market ... and forecasting of market sizes. The report also ... and opportunities impacting it along with the adoption ...
Breaking Biology Technology:PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5
Cached News: