HOME >> BIOLOGY >> NEWS
Heavy metal research is music to biologists' ears

Crab and lobster are more than perennial summer favorites--they are also a good dietary source of copper. Yes, the stuff of pennies is crucial for life--the metal copper is an important helper to many cellular enzymes, including superoxide dismutase (SOD), which sops up dangerous "free radicals" that accumulate inside cells. Defects in SOD have been linked to some inherited forms of amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.

In an important advance in understanding the molecular underpinnings of this disease, scientists supported by the National Institute of General Medical Sciences (NIGMS) have deciphered the three-dimensional structure of a yeast copper "chaperone" protein, a molecule that transports copper to the SOD enzyme. Although copper is necessary for life, it is a potentially toxic "heavy metal" that--in the wrong cellular locale--can damage other molecules, and in some cases can even cause disease. As the name suggests, the copper chaperone protein protects copper from unwanted cellular interactions and safely delivers it to its destination.

The work also identifies a potential target for developing drugs to treat Lou Gehrig's disease, a uniformly fatal condition.

The research report appears in the August 1999 issue of the journal Nature Structural Biology.

A little over six years ago, scientists first linked Lou Gehrig's disease to SOD by showing that some people with the disease had "misspellings" in the gene that encodes SOD. The finding prompted a series of studies aimed at determining how copper gets inserted into this prevalent cellular enzyme. In 1997, Dr. Valeria Culotta of The Johns Hopkins University, collaborating with Dr. Thomas O'Halloran of Northwestern University, first discovered a protein that ferries copper molecules throughout a yeast cell; they coined it a copper chaperone. (Further research has shown that the yeast chaperone is very similar to its counterpart in humans.) Around the s
'"/>

Contact: Alison Davis
davisa@nigms.nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
28-Jul-1999


Page: 1 2 3

Related biology news :

1. Heavy consumption of tainted fish curbs adult learning and memory
2. Old Sins Industrial Metabolism, Heavy Metal Pollution, and Environmental Transition in Central Europe
3. Engineered Bacteria Scavenge Heavy Metals
4. Dartmouth Medical School Researchers Discover Heavy Metal Contamination In Northern Mexico
5. Heavy Traffic At The Nuclear Pore: How Proteins And RNA Leave The Cell Nucleus
6. Ecological Farming May Cause More Heavy Metals In The Soil
7. PET Project Helps Reduce Pollution Threat From Heavy Metals
8. Purdue study finds antioxidant protects metal-eating plants
9. Innovative ceramic-on-metal hip replacements to undergo clinical trials
10. A new hope for heavy metal contaminated soils
11. UCSD biologists discover key step for designer plants that could clean up heavy metals

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Heavy metal research music biologists ears

(Date:4/13/2015)... April 13, 2015 According ... "Global Biometrics Market Forecast & Opportunities, 2020", the global ... of around 14% till 2020. The biometrics market ... scale implementation and review of biometric management systems. ... new products with greater efficiency, are resulting in ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ... Competitive Profiles - NEC" report to their offering. ... will continue to supply a range of IT security ... company focus on the development of a Big Data ... in the Asia-Pacific region is ...
(Date:4/8/2015)... N.C. , April 8, 2015  Infinisource, ... solutions and services, and Morpho, a leading supplier ... partnership to produce the market,s most advanced biometrically-enabled ... Infinisource,s iSolved NXG time clock is setting a ... and labor data for the small and mid-size ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
(Date:4/27/2015)... y HEIDELBERG , Alemania, April ... obtiene la patente para un nuevo receptor utilizando tecnología ... una necesidad no cubierta en el tratamiento de millones ... Molecular Health ha anunciado hoy que ha recibido una patente ... patente apoya el descubrimiento de Molecular Health de que ...
(Date:4/27/2015)... , April 27, 2015 ... this release, please scroll to bottom . ... equities: Lexicon Pharmaceuticals Inc. (NASDAQ: LXRX ), ... Pharmaceuticals Corporation (NASDAQ: SNTA ), Spectrum Pharmaceuticals ... (NASDAQ: MDVN ). Free research report on ...
(Date:4/27/2015)... 2015 DryLet, LLC a biotechnology ... such as animal waste reduction, bioremediation, wastewater treatment, ... wastewater treatment plants and restaurant kitchen settings, announced ... Texas Commission on Environmental Quality (TCEQ) Environmental Trade ... , The company will highlight three of its ...
(Date:4/27/2015)... Elsevier , a world-leading provider of scientific, technical ... Office   have announced the winners of the Qatar University ... last week at Qatar University, ... guests representing Qatar,s top scientific community. ... Al-Misnad , President of Qatar University. ...
Breaking Biology Technology:Molecular Health obtiene la patente para un nuevo receptor 2Molecular Health obtiene la patente para un nuevo receptor 3Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 2Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 3Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 4Market Updates on Biotech Stocks -- Lexicon Pharma, Idera Pharma, Synta Pharma, Spectrum Pharma, and Medivation 5DryLet to Showcase Multiple Products at Texas Commission on Environmental Quality Trade Fair and Conference May 5-6 in Austin, Texas 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 3Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 4Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 5
Cached News: