HOME >> BIOLOGY >> NEWS
Hemochromatosis, inflammation and anemia

Patients with inflammatory diseases such as arthritis, chronic infections and some types of cancer, often become anemic a condition called anemia of chronic disease (ACD). While ACD rarely kills patients, it can make their lives miserable. A discovery at EMBL, in collaboration with researchers at Children's Hospital Boston and Harvard Medical School, now links the gene HFE to ACD. The HFE gene is mutated in patients suffering from the common iron overload disease hemochromatosis. This finding gives hope that one day an effective and specific therapy may be developed to treat ACD (featured in Nature Genetics, April 18, 2004).

When people are infected with microbes, the level of iron in their blood drops. This has an important function: iron is essential for the growth of infectious microbes, so one way for the body to fight back is to lower the amount of iron in circulation.

"Unfortunately, while this decrease in iron hinders the spread of parasites and is beneficial in the short term, it can cause anemia," notes EMBL Group Leader Matthias Hentze. "During a long term inflammatory condition, low levels of iron can starve the bone marrow of this metal which is essential for blood cells, leading to ACD."

Because the anemia is a consequence of a natural immune defense, it has been difficult to think of a therapy that wouldn't also disturb the immune system itself.

Now scientists may have found a way to combat the anemia of chronic diseases by blocking the action of only one gene HFE without having much effect on the rest of the immune response, and without any serious consequences for the organism.

HFE is the gene mutated in the common genetic disease hemochromatosis, a condition in which the body becomes overloaded with iron. Researchers believe that when there are increased iron levels in the body, HFE signals to another molecule, an iron hormone called hepcidin. The role of hepcidin is to decrease the level of iron
'"/>

Contact: Trista Dawson
dawson@embl.de
49-622-138-7452
European Molecular Biology Laboratory
18-Apr-2004


Page: 1 2

Related biology news :

1. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
2. UCSD researchers are first to demonstrate molecular link between inflammation and cancer
3. Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics
4. Cannabinoids spell relief in colon inflammation
5. Gene with key role in replicating pox viruses also halts inflammation
6. Study reveals important new factor in cystic fibrosis lung inflammation
7. Hopkins researchers discover how nitric oxide prevents blood vessel inflammation
8. Gene mutation responsible for Chrohns disease inflammation identified in Temple study
9. Novel proteins designed that block inflammation regulator associated with rheumatoid arthritis
10. Respiratory manifestations may be secondary to inflammation in cystic fibrosis patients
11. Once weekly ENBREL significantly reduced rheumatoid arthritis pain, inflammation & improved function

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... ... , ... Lajollacooks4u has expanded its team as it gears up for a ... seen record growth in 2019, having hosted a multitude of team-building events and cooking ... visited the company’s La Jolla-based venue, and Lajollacooks4u has worked hard to accommodate the ...
(Date:8/27/2019)... Fla. (PRWEB) , ... August 27, 2019 , ... ... in life science and drug development. This episode is scheduled to broadcast 4Q/2019. ... explore Debiopharm, a biopharmaceutical research, development, investment and manufacturing company. The show will ...
(Date:8/21/2019)... ... August 20, 2019 , ... Cutting Edge ... for the spine, today announced the 510(K) clearance of its novel SI joint ... is proven to improve osseointegration through superior hydrophilicity and optimized surface chemistry, as ...
Breaking Biology News(10 mins):
(Date:9/4/2019)... , ... September 03, 2019 ... ... of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, gene ... Science & Technology will present at the upcoming Nordic Life Science Days ...
(Date:8/27/2019)... ... 27, 2019 , ... Dr. Kim Carlson is a veterinary surgeon practicing in ... Surgical Group , a new surgical practice in San Mateo. She is currently ... more veterinary specialists as the practice grows. , When asked about the opening of ...
(Date:8/15/2019)... (PRWEB) , ... August 15, 2019 , ... ... Scientific Advisory Board. Mr. Lawrence is a member of the Institute of Food ... Safety and Health (IFSH) Advisory Board, Joint Institute for Food Safety and Applied ...
(Date:8/6/2019)... ... August 06, 2019 , ... The San Diego Biotechnology ... the biweekly SDBN BUZZ podcast focused on connecting the region’s biotech community and ... to promote the region and attract external employers, investors, scientists, and others who ...
Breaking Biology Technology:
Cached News: