HOME >> BIOLOGY >> NEWS
Hepatitis E virus infection may be widespread in rats

d," says Robert H. Purcell, M.D., chief of the hepatitis viruses section in NIAID's Laboratory of Infectious Diseases and senior author of the study. "It may be that the high prevalence of HEV antibodies in the absence of disease is due to infection with a strain of HEV that doesn't cause disease. Another possibility is that animals serve as reservoirs of HEV and pass a weakened form of the virus on to humans."

Dr. Purcell and his colleagues recently isolated HEV from swine in the United States, suggesting one possible source of exposure. However, HEV antibodies are detected primarily among residents of urban areas in the United States, where people rarely encounter pigs. Rats, on the other hand, have been ubiquitous city-dwellers for hundreds of years.

"Our data strongly suggest that many wild rats in the United States are naturally infected by HEV," says Dr. Purcell. "A major question is whether the HEV strain infecting rats is a new strain unique to rats or a variant of already recognized HEV strains."

To answer that question the researchers will need to isolate and characterize the rat virus, something they were unable to do in the current study. Their data suggest that rats become infected with HEV early in life. Other studies have shown that HEV disappears from the blood soon after HEV antibodies are produced. The researchers' best hope for isolating the virus, therefore, lies in trapping young rats that recently have been infected with HEV.

Dr. Purcell and his colleagues will attempt to pass the virus from infected wild rats to rats raised in the laboratory. In addition to providing clues about the source of HEV antibodies in humans, their efforts could result in an inexpensive new animal model for studying HEV infection, says Dr. Purcell. Currently, scientists must use expensive primate models to study the virus.

"Rat HEV has probably been around a long time," says Dr. Purcell. "We still do not know the source of the high pre
'"/>

Contact: John Bowersox
jbowersox@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
19-Aug-1999


Page: 1 2 3

Related biology news :

1. Risk of Hepatitis E from consumption of deer?
2. Hepatitis C infection does not alter HIV progression or treatment
3. Need, potential for Hepatitis C vaccine highlighted by Hopkins study
4. Hepatitis E recovered from rats in Los Angeles
5. Hepatitis C drug overwhelms virus with flood of mutations - surprising mechanism may improve anti-viral treatments, UCSF study finds
6. Explaining the persistence of Hepatitis C
7. High percentage of Hepatitis C patients take herbs and vitamins, according to Rush survey
8. Jefferson scientists show drug is effective against a Hepatitis C Virus model in the laboratory
9. Hepatitis C is not a silent disease
10. Hepatitis Cs interferon resistance mechanism discovered
11. Immune Response To Hepatitis B Spares Liver Cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: