HOME >> BIOLOGY >> NEWS
High Blood Pressure Caused By Salt Retention May Be Related To Oncogenes Implicated In Cancer

SAN FRANCISCO--Sodium transport - the kidney function that regulates the level of salt in the kidney and bloodstream and, ultimately, blood pressure, may be intimately related to some of the same oncogenes that have been implicated in the unchecked cellular growth of cancer. Douglas Eaton, Ph.D., associate professor of physiology and pediatrics at Emory University and director of Emory's Center for Cell and Molecular Signaling, presents the findings at the Experimental Biology '98 Meeting in San Francisco on Monday.

Dr. Eaton and his colleagues examined genetic, hormonal and pharmacologic changes that affect the sodium channels, which are special protein molecules found in a type of kidney cell. Sodium channels act as a gatekeeper by retaining salt in the kidney or by allowing it to enter the bloodstream in response to changes in blood pressure. Small alterations in these molecules cause them to retain too much salt, which can lead to high blood pressure. About 30 percent of people who have hypertension, or high blood pressure, are reacting to the buildup of too much sodium.

"If the sodium channels are too active," says Dr. Eaton, "then people retain sodium, causing water buildup and an abnormal rise in blood pressure."

Hypertension affects an estimated 62 million Americans and is an underlying cause of heart attacks, heart failure and strokes, as well as kidney failure. Some people have a specific, genetic abnormality that affects the sodium channels, but in other people there is nothing obviously wrong.

"In this other group of people, the sodium channels are switched on or off incorrectly by another molecule," says Dr. Eaton.

The steroid hormone aldosterone regulates how much sodium is released or retained by the sodium channels. In turn, steroid hormones like aldosterone work by switching on and off
'"/>

Contact: Sarah Goodwin
sgoodwi@emory.edu
404-727-3366
Emory University Health Sciences Center
20-Apr-1998


Page: 1 2

Related biology news :

1. Blood pressure hormone may inhibit growth of lung cancer
2. Blood tests identify patients on dialysis at high risk for death from cardiovascular disease
3. Blood banking systems improving in China, more progress needed
4. Blood proteins tied to inflammation
5. Bloodworms way with copper likely provides paradigm for new materials
6. Blood markers may reflect newborns potential of contracting HIV
7. Blood stem cells carry targeted genes
8. Blood vessels trigger development of the pancreas
9. Blood vessels found to signal chain of destruction in bone diseases
10. Blood markers associated with autism and mental retardation
11. Blood test for diagnosing schizophrenia

Post Your Comments:
(Date:7/27/2014)... have found that targeting a molecule in blood vessels ... research published in Nature today (Sunday)., The ... University of London, have found that a molecule, called ... itself after chemotherapy or radiotherapy, which kill cancer cells ... blood vessels that grew in melanoma or lung cancer ...
(Date:7/25/2014)... on the land now called California, and many of ... plants they used for food, fuel, tools, and ritual. ... habitat and natural resources. , Frank Lake, an ecologist ... lead a field trip to the Stone ... America,s 99th Annual Meeting, in Sacramento, Cal. this August. ...
(Date:7/25/2014)... published online in the International Journal of Cancer ... preventing cervical cancer based on findings showing successful reduction ... a discrete population of cells in the cervix. ... at squamocolumnar junction cells, or SCJ cells. These cells ... as the origins of cervical cancer. A research team ...
Breaking Biology News(10 mins):New drug target can break down cancer's barrier against treatment 2Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3Clearing cells to prevent cervical cancer 2
(Date:7/28/2014)... July 28, 2014 According to ... Market Research "Regenerative Medicine (Bone and Joint) Market ... Tissue Engineering; By Applications - Bone Graft Substitutes, ... - Global Industry Analysis, Size, Share, Growth, Trends ... medicine (bone and joint) market was valued at ...
(Date:7/28/2014)... , July 28, 2014  David Hardison, Ph.D., ... by Deloitte , has been elected chairman of ... Consortium, a non-profit working to establish common protocols ... as it relates to electronic health records. ... mission of collaborating with organizations across the research ...
(Date:7/28/2014)... The global market for biotechnology is ... to a new study by Grand View Research, Inc. ... effective vaccines and drugs in an attempt to improve ... expected to drive market demand over the next six ... via the use of genetically engineered seeds is expected ...
(Date:7/26/2014)... 26, 2014 Canada Endoscopy Visualization ... data on the Canada Endoscopy Visualization Systems market. ... dollars, volume (in units) and average prices (in ... Visualization Systems, Mid-Range Endoscopy Visualization Systems and Low-End ... http://www.marketresearchreports.biz/analysis/213254 . , The report also provides ...
Breaking Biology Technology:Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Regenerative Medicine Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5
Cached News: