High Blood Pressure Caused By Salt Retention May Be Related To Oncogenes Implicated In Cancer

SAN FRANCISCO--Sodium transport - the kidney function that regulates the level of salt in the kidney and bloodstream and, ultimately, blood pressure, may be intimately related to some of the same oncogenes that have been implicated in the unchecked cellular growth of cancer. Douglas Eaton, Ph.D., associate professor of physiology and pediatrics at Emory University and director of Emory's Center for Cell and Molecular Signaling, presents the findings at the Experimental Biology '98 Meeting in San Francisco on Monday.

Dr. Eaton and his colleagues examined genetic, hormonal and pharmacologic changes that affect the sodium channels, which are special protein molecules found in a type of kidney cell. Sodium channels act as a gatekeeper by retaining salt in the kidney or by allowing it to enter the bloodstream in response to changes in blood pressure. Small alterations in these molecules cause them to retain too much salt, which can lead to high blood pressure. About 30 percent of people who have hypertension, or high blood pressure, are reacting to the buildup of too much sodium.

"If the sodium channels are too active," says Dr. Eaton, "then people retain sodium, causing water buildup and an abnormal rise in blood pressure."

Hypertension affects an estimated 62 million Americans and is an underlying cause of heart attacks, heart failure and strokes, as well as kidney failure. Some people have a specific, genetic abnormality that affects the sodium channels, but in other people there is nothing obviously wrong.

"In this other group of people, the sodium channels are switched on or off incorrectly by another molecule," says Dr. Eaton.

The steroid hormone aldosterone regulates how much sodium is released or retained by the sodium channels. In turn, steroid hormones like aldosterone work by switching on and off

Contact: Sarah Goodwin
Emory University Health Sciences Center

Page: 1 2

Related biology news :

1. Blood pressure hormone may inhibit growth of lung cancer
2. Blood tests identify patients on dialysis at high risk for death from cardiovascular disease
3. Blood banking systems improving in China, more progress needed
4. Blood proteins tied to inflammation
5. Bloodworms way with copper likely provides paradigm for new materials
6. Blood markers may reflect newborns potential of contracting HIV
7. Blood stem cells carry targeted genes
8. Blood vessels trigger development of the pancreas
9. Blood vessels found to signal chain of destruction in bone diseases
10. Blood markers associated with autism and mental retardation
11. Blood test for diagnosing schizophrenia

Post Your Comments:

(Date:10/27/2015)... , Oct. 27, 2015 In the ... issues of concern for various industry verticals such as ... due to the growing demand for secure & simplified ... various ,sectors, such as hacking of bank accounts, misuse ... electronic equipment such as PC,s, laptops, and smartphones are ...
(Date:10/27/2015)... Synaptics Inc. (NASDAQ: SYNA ), the leader ... adopted the Synaptics ® ClearPad ® Series ... newest flagship smartphones, the Nexus 5X by LG and ... --> --> Synaptics works closely with ... in the joint development of next generation technologies. Together, ...
(Date:10/26/2015)... LAS VEGAS , Oct. 26, 2015 ... an innovator in modern authentication and a founding member ... launch of its latest version of the Nok Nok™ ... to use standards-based authentication that supports existing and emerging ... Suite is ideal for organizations deploying customer-facing applications that ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , ... November 25, 2015 , ... ... uBiome, were featured on AngelList early in their initial angel funding process. Now, ... syndicate for individuals looking to make early stage investments in the microbiome space. ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... The United ... recipient of the 2016 USGA Green Section Award. Presented annually since 1961, the USGA ... his or her work with turfgrass. , Clarke, of Iselin, N.J., is ...
(Date:11/24/2015)... , Nov. 24, 2015 Halozyme Therapeutics, Inc. (NASDAQ: ... in New York on Wednesday, December 2 ... Torley , president and CEO, will provide a corporate overview. ... York at 1:00 p.m. ET/10:00 a.m. PT . ... relations, will provide a corporate overview. --> th ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... But unless it is bound to proteins, copper is also toxic to cells. ... at Worcester Polytechnic Institute (WPI) will conduct a systematic study of copper in ...
Breaking Biology Technology:
Cached News: