HOME >> BIOLOGY >> NEWS
High Levels of Vitamin C Prove Toxic to HIV

NEW YORK, N.Y., February 28, 1997 -- Laboratory research by Memorial Sloan-Kettering Cancer Center scientists shows that HIV-infected immune cells take in more vitamin C and glucose than their healthy counterparts, which may aid replication of the AIDS virus. At the same time, however, extremely high levels of the vitamin are more toxic to the HIV-infected cells than to healthy immune cells, the investigators report in the Feb. 28 issue of the Journal of Biological Chemistry.

HIV-infected cells grown in the laboratory appear to be more sensitive to the toxic effects of vitamin C, explained Dr. David W. Golde, Physician-in-Chief of Memorial Hospital and senior author of the paper. At the same levels of exposure, the HIV-infected cells took in more vitamin C than uninfected immune cells.

The laboratory research provides the foundation to begin to understand the relationship among vitamin C, HIV infection, and cell metabolism, and may lead to new therapeutic targets to counter the AIDS virus, he added. Vitamin C is essential to the human body and is necessary for normal function of the immune system.

The researchers studied vitamin C uptake and its effects on AIDS-virus production in HIV-infected and healthy immune cells, after finding in previous studies that cancer cells also take in more glucose and vitamin C than normal cells. In addition, Dr. Golde and his colleagues were the first to prove, in 1993, that the same molecule that allows glucose into cells also serves as a route for vitamin C to enter. Although vitamin C is used by cells in one chemical form (ascorbic acid), it enters cells in another form (dehydroascorbic acid). Once inside the cell, this vital nutrient is reconverted to its original form, whose different shape and size prevent it from leaving the cell.

This series of studies prompted Dr. Golde and his colleagues to ask whether HIV-infected cells
'"/>

Contact: Stacey Harris
harriss@mskcc.org
212-639-3628
Memorial Sloan-Kettering Cancer Center
4-Mar-1997


Page: 1 2 3

Related biology news :

1. The Reason The French Have Low Levels Of Heart Disease
2. Marine Life In South Pacific Region Found To Be Impervious To Oceans Highest Arsenic Levels
3. Breast Milk Of Women Who Eat Lake Ontario Fish Contains High Levels Of PCBs, UB Study Finds
4. For First Time In 40 Years National Jewish Researchers Report Chronic Beryllium Disease Caused By Extremely Low Levels Of Exposure
5. Residential Dust Control Fails To Reduce Blood Lead Levels In Children
6. New Hampshire Study Shows Well Water Has Higher Arsenic Levels Than Municipal Water
7. Higher Levels Of Protein May Predict Heart Disease
8. Elevated Blood Levels Of Inactive TPA Linked To Increased Stroke Risk In Young Women
9. Alcohol Consumption, Resistance To Its Effects Related To Levels Of Neurotransmitter, Say UW Researchers
10. USC Scientists Find That Multi-Vitamin Use And Hormone Replacement Therapy MayLower Levels Of Homocysteine
11. Stress Hormone Levels Predict Length Of Gestation In Human Pregnancy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... , ... Lajollacooks4u is delighted to announce it has been named as one ... given only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, as ... To qualify for the Certificate of Excellence –- an award that only 10 percent ...
(Date:5/31/2019)... ... May 30, 2019 , ... Researchers from Ambry Genetics ... significant differences in the prevalence of hereditary genetic mutations, also called germline mutations, ... women. Results will be presented at the 2019 American Society of Clinical Oncology ...
(Date:5/26/2019)... ... ... Zolgensma (Novartis, AveXis), an AAV-delivered gene therapy used to treat spinal muscular atrophy ... by the Food and Drug Administration today. , The treatment is now ... United States and the second-ever approved treatment for SMA. , FDA granted priority review ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... ... ... Personalized Stem Cells, Inc (“PSC”), a human adipose-derived stem cell ... of a person’s own adipose-derived stem cells to treat their osteoarthritis. The first clinical ... IND is the first of several planned clinical trials which will enable qualified PSC-enrolled ...
(Date:6/11/2019)... ... June 11, 2019 , ... ... Clinic, a national leader in opioid treatment, announced today they are partnering to ... , Mytonomy recently deployed its virtual care platform at the Mayo Clinic to ...
(Date:5/31/2019)... City, California (PRWEB) , ... ... ... allowance of our patent applications from the USPTO providing proprietary interest to ... AND METHOD FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights ...
(Date:5/21/2019)... ABABA, Ethiopia (PRWEB) , ... May 21, 2019 ... ... für Brauerei in Berlin (VLB) today officially opened the inaugural Africa Brewing Conference ... brewing and malting industry in Africa. The event, which is supported through a ...
Breaking Biology Technology:
Cached News: