High Levels of Vitamin C Prove Toxic to HIV

also take in higher-than-normal levels of glucose and vitamin C. In the new study, led by Dr. Coralia Rivas and Dr. Juan Carlos Vera of Memorial Sloan-Ketterings Molecular Pharmacology and Therapeutics Program, the researchers studied the effects of vitamin C in four HIV-infected cell lines and four identical, but uninfected, immune cell lines. They found that compared with the healthy cells, the HIV-infected cells:

  • have greater numbers of specialized cell-surface receptors through which glucose and vitamin C enter;
  • experience a three- to five-fold increase in the uptake of vitamin C in the form of dehydroascorbic acid; and
  • accumulate two to three times more vitamin C in the form of ascorbic acid.

We noticed that shortly after infection with HIV, the cells put out more glucose-transport molecules on their surfaces, which allow more vitamin C to enter, Dr. Golde said. HIV-infected cells seem to want more glucose and vitamin C. But if they take in too much vitamin C, they die.

When the researchers exposed both HIV-infected and healthy immune cells to varying levels of vitamin C, they observed a range of effects. At levels of vitamin C comparable to those normally found in the body, the nutrient either had no effect or caused a slight increase in viral replication. But exposure to high vitamin C levels more than 20 times greater than normal decreased replication of the AIDS virus and was generally more toxic to HIV-infected cells than to the uninfected cells.

Such high blood levels of vitamin C cant be achieved by taking it orally because most supplemental vitamin C is excreted in the urine, Dr. Golde said. He and his colleagues are planning follow-up studies of vitamin Cs effects in patients infected with the AIDS virus.

Memorial Sloan-Kettering Cancer Center is the worlds oldest and largest private institution devoted to prevention, patient care, research, and education in cancer. Throughout its long, distinguished history,

Contact: Stacey Harris
Memorial Sloan-Kettering Cancer Center

Page: 1 2 3

Related biology news :

1. The Reason The French Have Low Levels Of Heart Disease
2. Marine Life In South Pacific Region Found To Be Impervious To Oceans Highest Arsenic Levels
3. Breast Milk Of Women Who Eat Lake Ontario Fish Contains High Levels Of PCBs, UB Study Finds
4. For First Time In 40 Years National Jewish Researchers Report Chronic Beryllium Disease Caused By Extremely Low Levels Of Exposure
5. Residential Dust Control Fails To Reduce Blood Lead Levels In Children
6. New Hampshire Study Shows Well Water Has Higher Arsenic Levels Than Municipal Water
7. Higher Levels Of Protein May Predict Heart Disease
8. Elevated Blood Levels Of Inactive TPA Linked To Increased Stroke Risk In Young Women
9. Alcohol Consumption, Resistance To Its Effects Related To Levels Of Neurotransmitter, Say UW Researchers
10. USC Scientists Find That Multi-Vitamin Use And Hormone Replacement Therapy MayLower Levels Of Homocysteine
11. Stress Hormone Levels Predict Length Of Gestation In Human Pregnancy

Post Your Comments:

(Date:8/1/2019)... ... July 30, 2019 , ... Keck Graduate Institute (KGI) President ... Professor in Bioprocessing and Director of the Amgen Bioprocessing Center, effective July 29, ... and possesses more than 25 years of global experience in bioprocessing,” Schuster said. ...
(Date:8/1/2019)... (PRWEB) , ... August 01, 2019 , ... USDM Life ... and Solutions , will deliver a detailed webinar addressing challenges with the upcoming ... the area of UDI and has held a variety of positions over his 26 ...
(Date:7/24/2019)... ... July 24, 2019 , ... NDA ... a quality assurance expert with more than 20 years of experience working in ... has joined the firm as an Expert Consultant. , Dr. Hartzfeld has experience ...
Breaking Biology News(10 mins):
(Date:6/26/2019)... ... June 26, 2019 , ... Alice Branton today released research ... physicochemical properties of Magnesium Gluconate, which can prove to be beneficial for treating Hypomagnesemia. ... characteristic differentiation peak, change in crystallite size , Over 142% increase in ...
(Date:6/11/2019)... ... , ... Thought Technology Ltd is pleased to announce the ... Ltd as its authorised distributor for the UK and Ireland. , Thought ... clinical assessment protocols to treat stress related disorders as well as provide treatment ...
(Date:6/11/2019)... ... June 11, 2019 , ... ... Personalized Stem Cells Inc. (PSC) , has announced that their GMP facility for ... and Drug Branch for manufacturing. This is an important milestone for VetStem ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... proprietary interest to our methodology, processes, and diagnostic techniques. The patent applications ... Somnology’s IP rights including our proprietary sleep scoring methodology. The approval and ...
Breaking Biology Technology:
Cached News: