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Higher Levels Of Protein May Predict Heart Disease

besity, as measured by body mass index, also led to higher levels of C- reactive protein. "Just being obese can cause the system to become inflamed," he said

Those whose bodies are still sensitive to insulin averaged 1.2, while those who had developed resistance to insulin averaged 3.5 micrograms per milliliter.

"These results may provide an insight into a mechanism for several established cardiovascular risk factors," Howard said. In the IRAS study, at least, C-reactive protein "has strong associations with measures of the metabolic syndrome."

Interesting, he said, two long known risk factors for heart disease -- cigarette smoking and increased thickness of the wall of the carotid artery -- did not lead to increases in C-reactive protein.

Howard called for long term studies to determine where increased levels of the C-reactive protein in the blood predict heart attracks and strokes in people who have increased insulin resistance and diabetes.

The study was funded by the National Heart, Lung and Blood Institute.


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Contact: Robert Conn or Jim Steele
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
29-Mar-1999


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