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Homocysteine: A Possible Risk Factor For Alzheimer's Disease

er, testing this hypothesis will require long and costly trials.'

A full paper describing the results of this study is being considered for publication in a medical journal, and no further details of the research will be issued until the date of publication.

The study has been supported by a long-term grant to the University of Oxford's Department of Pharmacology by Bristol-Myers Squibb Co, and to the Department of Pharmacology at the University of Bergen from the Norwegian Council on Cardiovascular Disease.

Since its foundation in 1988, OPTIMA has been conducting research into changes which occur in the brain as part of the ageing process. In revealing the differences between normal brain ageing and diseases like Alzheimer's disease, OPTIMA aims to lay the foundations for the development of new forms of prevention and treatment.

The project's work was examined in two hour-long documentaries, `Assault on the Mind', shown on Channel 4 in the UK on April 21 and 28. The programme outlined the methods and main achievements of OPTIMA, including:

  • Development of an accurate diagnostic procedure for Alzheimer's disease in life by a combination of structural and functional brain imaging.

  • Discovery of a biological `state' marker, the thickness of the medial temporal lobe, that can be used to follow the progression of Alzheimer's disease.

Notes to editors: No interviews or further comments will be given by members of the OPTIMA team until publication of the full paper. More details about OPTIMA's research are available on the OPTIMA website at http://www.pharm.ox.ac.uk/optima.htm

Any additional queries should be addressed to the University Press Office on 01865 278181/2/3.


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Contact: Gill Sanders or Nicky Old
gill.sanders@admin.ox.ac.uk
44 (0)1865 278181
University of Oxford
28-Apr-1998


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