HOME >> BIOLOGY >> NEWS
Hopkins And International Team Maps First Major Cancer Gene To X Chromosome

Johns Hopkins researchers, collaborating with an international team of geneticists, have pinpointed the site of the first gene for a major cancer located on the human X chromosome. The gene, for prostate cancer, may account for almost 20 percent of disease in families with a strong history of the cancer, the researchers say. It's the second prostate cancer susceptibility gene this group has mapped, and the first on the X chromosome, which men inherit from their mothers.

"This is clearly a major step toward understanding the factors that lead to prostate cancer," says Hopkins Urologist-in-Chief, Patrick C. Walsh, M.D., one of the study's authors. "We're still at the early stages in figuring out genetic involvement in prostate cancer, but this finding is real progress," says Hopkins geneticist, William Isaacs, Ph.D., a co-director of the study.

The research, reported in the October Nature Genetics, describes the new gene locus, called HPCX (for human prostate cancer on the X chromosome) as responsible for 15 to 20 percent of inherited forms of the diseases. Of the approximately 200,000 new cases diagnosed in the U.S. each year, an estimated 10 percent are inherited.

The study confirms researchers' long-held suspicion that the X chromosome might be important in prostate cancer. Since the 1960s, they have noted that a man's risk of prostate cancer tends to be higher if his brother has prostate cancer than if his father has the disease. That inheritance pattern characterizes genetic traits carried on the X chromosome and passed from mothers to sons, such as muscular dystrophy or hemophilia. The plausible explanation is that a prostate cancer susceptibility gene lies on the X chromosome.

"Mapping HPCX brings us one step closer to understanding the origins of prostate cancer, at least in some families," says Francis Collins, M.D., director of the National Human Genome Research Institute and an author from
'"/>

Contact: Gary Stephenson
gstephenson@jhmi.edu
(410) 955-5384
Johns Hopkins Medical Institutions
29-Sep-1998


Page: 1 2 3

Related biology news :

1. Hopkins scientists use blood proteins to detect ovarian cancer
2. Hopkins to found first center for comprehensive study of epigenetics
3. Hopkins scientists overcome main obstacle to making tons of short, drug-like proteins
4. Hopkins Marine Station honored by the American Society for Microbiology
5. Johns Hopkins gene hunters pinpoint new cancer gene target
6. Hopkins researchers identify transplantation antigens among Sioux Indians
7. Hopkins researchers discover how nitric oxide prevents blood vessel inflammation
8. Hopkins is first US institution to obtain powerful genotyping system
9. Dr. Robot tested at Hopkins
10. From Hopkins: Children may outgrow peanut allergies
11. OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2019)... , ... April 24, 2019 , ... ... announces today the award of U.S. patent 10,191,929, “Systems and Methods for SNP ... and more efficient to conduct a variety of advanced bioinformatic analyses, including SNP ...
(Date:4/18/2019)... and WALNUT CREEK, Calif. (PRWEB) , ... April ... ... management solution for the healthcare industry, today announced the launch of mSource® AI ... processing to extract deep knowledge of Medpricer customers’ supplier contracts, truly optimizing purchased ...
(Date:4/16/2019)... ... April 16, 2019 , ... HealthLink International, experts ... its new medical device facility on Friday, April 12. Headquartered in the Netherlands, ... new facility includes 108,500 square feet and houses 32 employees enabling HealthLink to ...
Breaking Biology News(10 mins):
(Date:4/25/2019)... , ... April 24, 2019 , ... ... Agents for sales and service organizations, today announced global availability of Inference ... providers and enterprises of all sizes to harness the power of Google’s ...
(Date:4/15/2019)... ... April 15, 2019 , ... ... of a $2 million bench plant expansion to increase production of methylene malonate ... the design and construction of Sirrus’ full-scale production facility, which is scheduled to ...
(Date:4/9/2019)... , ... April 09, 2019 , ... ... focused on increasing the capacity of life sciences organizations to accelerate innovation and ... Assurance platform in the past 12 months. , USDM’s Cloud Assurance ...
(Date:4/8/2019)... ... April 08, 2019 , ... US Capital Global ... $15 million preferred equity investment in the privately held pharmaceutical company, S1 Biopharma (“S1”). ... Lorexys, is targeted at female hypoactive sexual dysfunction disorder and is ready to begin ...
Breaking Biology Technology:
Cached News: