HOME >> BIOLOGY >> NEWS
Hopkins is first US institution to obtain powerful genotyping system

otide polymorphism, or SNP (pronounced "snip"). Several million SNPs already are known.

Geneticists have successfully correlated SNPs or other mutations with the incidence of some rare diseases such as cystic fibrosis. But determining genetic contributors to and causes of such common diseases as cancer has been a difficult, piecemeal process because these conditions involve multiple genetic changes that combine to affect health or disease.

"This genotyping technology lets you rapidly survey what amounts to the entire human genome for regions linked to a condition, and then, separately, to delve into the fine detail of very small regions of DNA to figure out what's really happening," says Scott.

With the appropriate controls and experimental set-up by trained technicians, the system determines the genotypes of all the samples and produces a score that rates the accuracy of the result.

"These genotypes can then be correlated with patient characteristics, health, tissue type or whatever it is you're studying," says Aravinda Chakravarti, Ph.D., director of the McKusick-Nathans Institute. "Instead of spending years just to get genotype information across the genome, now we can spend our time analyzing the data, looking for multiple genes rather than finding them one at a time. With this system we're well on our way to being able to do large-scale studies of complex human genetic diseases and to investigating the biological basis of individuals' susceptibility to disease."

The Illumina system's BeadArray technology uses dimpled fiberoptic strands in bundles no thicker than a pencil lead, each holding tens of thousands of tiny beads. Each bead is labeled with one of up to 1,300 DNA tags to unmask the version of a specific SNP in the sample. The fiberoptic bundles are then arrayed as in a 96-well plate.

The new facility will be housed at the Johns Hopkins Bayvie
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
14-Aug-2003


Page: 1 2 3

Related biology news :

1. Hopkins scientists use blood proteins to detect ovarian cancer
2. Hopkins to found first center for comprehensive study of epigenetics
3. Hopkins scientists overcome main obstacle to making tons of short, drug-like proteins
4. Hopkins Marine Station honored by the American Society for Microbiology
5. Johns Hopkins gene hunters pinpoint new cancer gene target
6. Hopkins researchers identify transplantation antigens among Sioux Indians
7. Hopkins researchers discover how nitric oxide prevents blood vessel inflammation
8. Dr. Robot tested at Hopkins
9. From Hopkins: Children may outgrow peanut allergies
10. OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine
11. Hopkins researchers find potential new treatment for children with chronic hepatitis C

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/8/2019)... ... May 07, 2019 , ... ... accepted into Forbes Technology Council, an invitation-only community for world-class CIOs, CTOs, ... a full-service biopharmaceutical cold chain engineering firm that guarantees confidence in a ...
(Date:5/7/2019)... ... 2019 , ... Landsec and Spartan Bioscience today announced they ... In May, Landsec will undertake trials using Spartan’s innovative Legionella test. Spartan’s test ... corrective action within hours instead of weeks. This test, if approved, could ...
(Date:5/2/2019)... ... 01, 2019 , ... uBiome, the leader in microbial genomics, ... General Counsel, as Interim Chief Executive Officer of uBiome, effective immediately. The Company’s ... There will also be an independent investigation into uBiome’s billing practices to be ...
Breaking Biology News(10 mins):
(Date:4/15/2019)... LOVELAND, Ohio (PRWEB) , ... April 15, 2019 ... ... and oligomers, has completed construction of a $2 million bench plant expansion to ... represents an important step in the design and construction of Sirrus’ full-scale production ...
(Date:4/10/2019)... ... April 10, 2019 , ... After more than three months of ... kitchen is equipped with updated appliances and modern lighting and fixtures, and will provide ... , “We’ve seen tremendous growth in the demand for our team-building events and ...
(Date:4/9/2019)... ... 2019 , ... The American Society of Gene & Cell Therapy (ASGCT) ... a new addition to the presidential line of succession, at the 22nd Annual ... leadership team for a three-year term (2019-2021). , All five incoming members of the ...
(Date:4/8/2019)... Zealand (PRWEB) , ... April 09, 2019 , ... ... infectious disease, the innovative non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has ... study of antibody repertoires is part of CZ Biohub’s efforts to establish new ...
Breaking Biology Technology:
Cached News: