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Hopkins researcher finds bone disease and growth defect may have common genetic basis

s well as how fast many proteins work.

Patients diagnosed with progressive osseous heteroplasia develop spontaneous bone fragments under the skin and deep inside their bodies. The fragments can be as large as rice grains and often cause acute pain by pressing against nearby nerve cells. The lesions caused by POH can be identified, leading to diagnosis soon after birth. Albright hereditary osteodystrophy is characterized by short stature, obesity, relatively short fingers and, often, endocrine problems. AHO is usually diagnosed during childhood. Although the actual incidence of AHO and POH in the population is unknown, Levine estimates one of every 100,000 individuals is affected by either of the disorders. The two diseases rarely occur together in a single person.


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Contact: David Bricker
dbricker@jhmi.edu
410-223-1728
Johns Hopkins Medical Institutions
9-Nov-2000


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