HOME >> BIOLOGY >> NEWS
Hopkins researchers develop method to predict response to chemotherapy

Researchers at the Johns Hopkins Oncology Center uncovered a genetic alteration that appears to predict how individuals with an aggressive type of brain cancer will respond to chemotherapy.

The discovery, published in the November 9, 2000, issue of the New England Journal of Medicine, emerged from analysis of tumor samples from 47 patients with glioma, all of whom received standard treatment with the drug, carmustine. In 19 of the patients, the methyl-guanine-DNA methyltransferase (MGMT) gene appeared in a chemically altered form and 12 of these 19 had significantly better responses to chemotherapy, including regression of the tumor and increased long-term survival. This is compared with one patient of 28 with unaltered MGMT genes who responded to the chemotherapy. Patients with altered MGMT genes lived an average of 13 months longer than the other patients.

The MGMT gene is altered through a biochemical process known as methylation. The Hopkins scientists speculate that the normal, so-called unmethylated MGMT genes support repair of DNA damage, including damage caused by chemotherapy drugs, and therefore inhibits effectiveness of the drug. When the gene is altered or methylated, however, repair activity is blocked, allowing the anticancer drugs to attack the cancer cells unchecked.

The researchers currently are investigating agents that will block the MGMT gene and increase tumor sensitivity to carmustine. "The ability to detect the methylated form of the MGMT gene may provide a new way of pre-selecting some cancer therapy based on a tumor's chemical profile," says James G. Herman, M.D., assistant professor of oncology at Johns Hopkins and principal investigator of the study.

"The most exciting aspect of this research is that we can begin applying it to therapy right away," says Manel Esteller, M.D., Ph.D., research fellow at the Oncology Center and first author of the paper. "We don't have to wait for new drugs to be develo
'"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
8-Nov-2000


Page: 1 2

Related biology news :

1. Hopkins scientists use blood proteins to detect ovarian cancer
2. Hopkins to found first center for comprehensive study of epigenetics
3. Hopkins scientists overcome main obstacle to making tons of short, drug-like proteins
4. Hopkins Marine Station honored by the American Society for Microbiology
5. Johns Hopkins gene hunters pinpoint new cancer gene target
6. Hopkins researchers identify transplantation antigens among Sioux Indians
7. Hopkins researchers discover how nitric oxide prevents blood vessel inflammation
8. Hopkins is first US institution to obtain powerful genotyping system
9. Dr. Robot tested at Hopkins
10. From Hopkins: Children may outgrow peanut allergies
11. OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
(Date:6/14/2017)... PARIS , June 15, 2017  IBM (NYSE: IBM ... the international tech event dedicated to developing collaboration between startups ... on June 15-17. During the event, nine startups will ... deliver value in various industries. ... in the international market, with a 30 percent increase in ...
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
Breaking Biology News(10 mins):
(Date:6/23/2017)... ... 23, 2017 , ... Biova, LLC., the leader in water soluble egg membrane ... Dr. Henig will bring a wealth of scientific experience in the food, beverage, nutrition ... and Scientific Officer of four major global companies in the last 4 decades. ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... announced the latest version of LimitLIS®, its rapidly growing Laboratory Information System. , ... user adoption, ensure installation integrity, and provide more customization options. Each of these ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ken Hanson, a medical ... Physik Instrumente USA, have been selected as this year’s recipients of two top awards ... have been invited along with other honorees to accept their awards at a banquet ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... of a redesigned, easier-to-navigate website for all six of their healthcare job ... nurses, dentists, pharmacists, physical and occupational therapists, and biotechnicians, DocCafe.com and the ...
Breaking Biology Technology:
Cached News: