HOME >> BIOLOGY >> NEWS
Hopkins researchers discover how nitric oxide prevents blood vessel inflammation

Johns Hopkins scientists investigating nitric oxide (NO) - the molecular messenger that contributes to body functions as wide-ranging as cell death, new blood vessel growth and erections - have figured out how it can block blood vessel inflammation and prevent clotting, a process that has long stumped biologists.

Reporting in the Oct. 17 issue of the journal Cell, cardiologist Charles J. Lowenstein, M.D., and his team observed that NO has the power to inhibit endothelial cells lining blood vessels from releasing inflammatory substances.

Normally, these cells activate a process called exocytosis (a release of substances) to start inflammation, releasing packets of molecules into the bloodstream that, like tiny hand grenades, explode and discharge compounds that trigger inflammation. NO can move in and target a protein within the endothelial cells, N-ethylmaleimide-Sensitive Factor (NSF), that stops the process from happening by blocking the ability of NSF to push out the molecules.

"Nitric oxide may regulate exocytosis this way in a variety of diseases," says Lowenstein, an associate professor of medicine at Hopkins. "For example, nitric oxide blocks exocytosis from platelets, preventing blood clots; exocytosis from neurons, decreasing neurotoxicity in strokes; and exocystosis from lymphocytes, reducing autoimmune damage."

The Hopkins scientists discovered NO's protective role in both cells and mice. They added NO to human endothelial cells in culture and discovered that it blocked the release of inflammatory compounds. The researchers then found that platelets stuck to blood vessels more often in mice that could not make NO, compared to normal mice.

The findings already have led Lowenstein's team to develop a novel drug to block exocytosis, thereby acting as an anti-clotting agent. It is a peptide that blocks exocytosis by a mechanism similar to that of nitric oxide. In laboratory tests in mice, the drug prevented tiny, d
'"/>

Contact: Karen Blum
kblum@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
17-Oct-2003


Page: 1 2

Related biology news :

1. Hopkins scientists use blood proteins to detect ovarian cancer
2. Hopkins to found first center for comprehensive study of epigenetics
3. Hopkins scientists overcome main obstacle to making tons of short, drug-like proteins
4. Hopkins Marine Station honored by the American Society for Microbiology
5. Johns Hopkins gene hunters pinpoint new cancer gene target
6. Hopkins researchers identify transplantation antigens among Sioux Indians
7. Hopkins is first US institution to obtain powerful genotyping system
8. Dr. Robot tested at Hopkins
9. From Hopkins: Children may outgrow peanut allergies
10. OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine
11. Hopkins researchers find potential new treatment for children with chronic hepatitis C

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/18/2018)... ... 18, 2018 , ... CP Merritt is a national champion Arabian horse that ... however in 2006, he had a medical setback that caused him to limp at ... from cartilage degeneration in his right rear fetlock. Such an injury could be ...
(Date:12/13/2018)... ... December 12, 2018 , ... Illumina, Kaiser Permanente, ResMed and ... The San Diego-based team-building and cooking events company has hosted an impressive guest ... cooking challenges. , Each group who visits receives a completely customized experience, ...
(Date:12/6/2018)... ... December 06, 2018 , ... Stewart has been ... contract services, throughout his career. During his recent five-year tenure with InSphero he ... established the commercial laboratory operations in Brunswick, Maine. Through these experiences, Stewart has ...
Breaking Biology News(10 mins):
(Date:1/8/2019)... ... ... The American Society of Gene and Cell Therapy’s (ASGCT) first class ... of industry leaders identified by the ASGCT board of directors. In total, the Society ... ASGCT members designing transformative pilot studies in gene and cell therapy as they prepare ...
(Date:1/4/2019)... ... January 02, 2019 , ... ... detect precancer and cancer cells in blood, has been named as a partner ... global biotech company developing cell therapies for cancer treatment, will use CellMax Life’s ...
(Date:12/19/2018)... ... 2018 , ... RURO, Inc., a leading provider of information ... The new release enhances the latest version of Limfinity®, RURO’s software framework, and ... , Validation protocols, and their execution, are critical for software systems scrutinized by ...
(Date:12/14/2018)... ... 2018 , ... NOVA OCULUS PARTNERS, LLC, and its Canadian ... immediately begin a clinical patient trial in Edmonton using their pioneering technology for ... has granted what is called an Investigational Testing Authorization for the trial, while ...
Breaking Biology Technology:
Cached News: