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Hopkins researchers find tourette drug has unexpected effect

A new study by Johns Hopkins Children's Center neurologists suggests that baclofen, a drug long thought to be effective in reducing the vocal and motor tics associated with Tourette syndrome, improves a patient's overall sense of well-being but does not significantly reduce tics.

"One of our conclusions is that baclofen helps as a treatment for Tourette syndrome, but it appears to improve something other than tics," says pediatric neurologist Harvey Singer, M.D., the report's lead author. "We originally thought baclofen would diminish patients' vocal and muscular tics but found, instead, that it's more useful in making patients feel less impaired by their tics."

In the first double-blind study of baclofen in patients with Tourette syndrome (TS), the research team scored the severity of TS symptoms of nine children between the ages of 8 and 14 years by using two standard indices, the Clinical Global Impression and Yale Global Tic Severity scales. Their report, which appears in this month's Neurology, reveals that patients in the study said they were less "impaired" while using the drug, even though phonic and motor tics did not significantly diminish in frequency.

While baclofen caused no major side effects among children in the placebo-controlled, crossover study, Singer says the drug may not be the most effective medication for suppressing tics in children with TS.

"Learning which kinds of drugs suppress tics the best may enable us to develop more effective treatments in the future," Singer says. "Testing medications in a rigorous setting represents the first step in identifying better therapies for TS."

The number of TS drugs doctors have to choose from may be quite large, since the underlying mechanism for tics may involve several brain chemicals, or neurotransmitters. As a "tier-1" drug, baclofen does not cause severe or long-term side effects, but its effect in reducing tics may be
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Contact: David Bricker
dbricker@jhmi.edu
410-223-1728
Johns Hopkins Medical Institutions
12-Mar-2001


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