Hopkins researchers test new molecular marker for prostate cancer

Hopkins cancer researchers have identified a new genetic culprit-with dietary links-in the initiation of prostate cancer. Their findings are reported in the April 15, 2002, issue of Cancer Research.

Cells taken from prostate cancers show a nine-fold increase in expression by a gene called AMACR (x-methylacyl-CoA racemase), a team of Hopkins investigators report. "This gene appears to play an important role in breakdown of branched chain fatty acid molecules such as those found in dairy products and beef," says William B. Isaacs, Ph.D., professor of urology and oncology at the Brady Urological Institute and Kimmel Cancer Center* at Johns Hopkins, and senior author of this study.

The Hopkins scientists caution that the link, if any, between increased expression of AMACR and eating beef and dairy foods is unclear and is the focus of ongoing research. The fatty acid molecules metabolized by an enzyme made by the AMACR gene are low in chicken and most fish. Several studies have shown diets high in red meat to be associated with an increased risk of prostate cancer.

"What we've learned about AMACR could not only serve as an excellent early marker for prostate cancer but also could identify new dietary or chemical means of preventing the disease," says Angelo M. De Marzo, M.D., Ph.D., co-author of the study and assistant professor of pathology, oncology, and urology at Johns Hopkins.

In the current study, Hopkins researchers used a comprehensive "gene chip" approach to simultaneously analyze the expression of more than 6500 genes and found that the AMACR gene was overexpressed in prostate cancers. They confirmed this by examining 168 prostate cancer tumors using a tissue microarray that rapidly evaluates gene expression. Using automated computer technology, researchers displayed the tissue microarrays to speed up the identification of relationships among genes and changes in normal and cancer cells.

More than 95 percent of

Contact: Vanessa Wasta
Johns Hopkins Medical Institutions

Page: 1 2

Related biology news :

1. Hopkins scientists use blood proteins to detect ovarian cancer
2. Hopkins to found first center for comprehensive study of epigenetics
3. Hopkins scientists overcome main obstacle to making tons of short, drug-like proteins
4. Hopkins Marine Station honored by the American Society for Microbiology
5. Johns Hopkins gene hunters pinpoint new cancer gene target
6. Hopkins researchers identify transplantation antigens among Sioux Indians
7. Hopkins researchers discover how nitric oxide prevents blood vessel inflammation
8. Hopkins is first US institution to obtain powerful genotyping system
9. Dr. Robot tested at Hopkins
10. From Hopkins: Children may outgrow peanut allergies
11. OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine

Post Your Comments:

(Date:2/6/2020)... , ... February 06, 2020 ... ... research organization (CRO) specializing in complex interventional medical device and pharmaceutical trials, ... Regulatory Strategy. In this newly established role, Dorothy oversees the development and ...
(Date:2/5/2020)... ... February 05, 2020 , ... LabKey has released Sample Manager, ... to sample processing within laboratories. , Built with input from a Product ... fields, LabKey Sample Manager has been designed with an intuitive user interface providing ...
(Date:1/29/2020)... ... January 29, 2020 , ... Jason Burke has joined CREO, ... providing consulting services for strategy, research and development and data governance to healthcare ... Managing Partner of CREO, an innovative management consulting and advisory firm based in ...
Breaking Biology News(10 mins):
(Date:1/27/2020)... , ... January 27, 2020 , ... ... it has secured financing from strategic investors led by Halma plc , ... existing investors Sonion, TDF Ventures, GII LLC, and WSJ Joshua Fund. A representative ...
(Date:1/22/2020)... ... January 20, 2020 , ... Brilliant, maker of ... the largest independent electronics distributor in the US, to make it easy for ... with leading smart home products from a single fulfillment partner. Ranging from entry-level ...
(Date:1/10/2020)... ... January 09, 2020 , ... ... services, today announced the acquisition of Cunesoft, a move that expands the company’s ... objectives of life sciences companies. , Based in Munich, Germany, Cunesoft provides intelligent ...
(Date:1/7/2020)... ... January 07, 2020 , ... Vuja De Sciences (“Vuja De”), ... recurrence, today announced the appointments of Chand Khanna, DVM, PhD, DACVIM (Onc), and Dr. ... Vuja De said, “We are delighted to welcome Chand and Lee as new directors. ...
Breaking Biology Technology:
Cached News: