HOME >> BIOLOGY >> NEWS
Hopkins scientists use blood proteins to detect ovarian cancer

Johns Hopkins Kimmel Cancer Center researchers have designed a blood test to detect ovarian cancer using three proteins found in common in the blood of women with the disease. Their preliminary studies with the new test suggest a molecular signature exclusive to this deadly cancer, known for its ability to remain undetected and spread quickly.

The Hopkins test, described in the August 15 issue of Cancer Research, identifies the proteins as a truncated form of transthyretin, a fragment of ITIH4 and apolipoprotein A1, teased out with a rigorous evaluation of protein patterns present in blood samples from ovarian cancer patients at several U.S. and international hospitals. Other research groups are evaluating ovarian cancer blood tests that use protein profiles consisting of tens of thousands of unidentified molecules.

"By identifying a select group of biomarkers specific to ovarian cancer, we not only know the proteins we are dealing with, but we can trace them back to alterations in the genetic code of ovarian cancer cells," says Daniel W. Chan, Ph.D., professor and director of the Biomarker Discovery Center at Johns Hopkins. "We are focusing on the markers for which we have good biological reasoning behind their selection, and hope to expand the panel of markers to catch as many variations in ovarian cancer proteins as possible."

This research was funded by the National Cancer Institute and Ciphergen Biosystems, which has licensed the test.

Chan and his co-workers emphasize that the test will not be commercially available for screening the population at large until completion of further validation studies in larger groups of patients. And even then, Chan notes, it is never going to be possible for a blood test to correctly diagnose 100 percent of cancerous tumors 100 percent of the time. "The goal is to come as close as possible to that by using this test in combination with other available diagnostic tools." They believe, howe
'"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
15-Aug-2004


Page: 1 2 3

Related biology news :

1. Hopkins to found first center for comprehensive study of epigenetics
2. Hopkins scientists overcome main obstacle to making tons of short, drug-like proteins
3. Hopkins Marine Station honored by the American Society for Microbiology
4. Johns Hopkins gene hunters pinpoint new cancer gene target
5. Hopkins researchers identify transplantation antigens among Sioux Indians
6. Hopkins researchers discover how nitric oxide prevents blood vessel inflammation
7. Hopkins is first US institution to obtain powerful genotyping system
8. Dr. Robot tested at Hopkins
9. From Hopkins: Children may outgrow peanut allergies
10. OXiGENE announces launch of ophthalmic clinical trial at The Johns Hopkins School of Medicine
11. Hopkins researchers find potential new treatment for children with chronic hepatitis C

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/7/2019)... ... 07, 2019 , ... Landsec and Spartan Bioscience today announced ... , In May, Landsec will undertake trials using Spartan’s innovative Legionella test. Spartan’s ... take corrective action within hours instead of weeks. This test, if approved, ...
(Date:5/2/2019)... ... 2019 , ... Philadelphia intellectual property law firm Panitch ... Ph.D., a registered patent agent, has joined the firm as a new member ... technical support and scientific expertise in the pharmaceutical and biotechnical arts and assists ...
(Date:5/2/2019)... ... May 01, 2019 , ... Gateway Genomics ... future children, announces a new publication titled, “ Self-Collection of Maternal Blood for ... Child Health. Previous studies had only shown early gender determination using venous blood. ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... ... May 13, 2019 , ... Leak ... instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is excited ... website aims to improve LDA’s ability to communicate directly with the marketplace; serving ...
(Date:5/4/2019)... ... 03, 2019 , ... Diopsys Inc, the world leader in ... vision test, a new full field electroretinography (ffERG) protocol designed to detect ... Americans will have glaucoma, with black Americans having the highest prevalence rate. This ...
(Date:5/2/2019)... ... 02, 2019 , ... Boston Robotic Hair Restoration announces the ... the days of painful hair transplant procedures. Boston Robotic Hair Restoration offers the ... robotic intelligent solution to offer a minimally invasive procedure. With the ARTAS® iX ...
(Date:4/16/2019)... SAN ANTONIO (PRWEB) , ... April 16, 2019 ... ... biometrics-based human identification systems, applications, and technology, today announced that Bank South Pacific ... through a competitive RFP process. The bank awarded Fulcrum a contract to deliver ...
Breaking Biology Technology:
Cached News: