Hormonal regulation of glucose production by fat cells

Since the discovery of the satiety factor leptin, it has been clear that fat should be regarded not solely as a storage site for lipids, but also as an endocrine tissue. The discovery of resistin and Acrp30 extended this finding and showed that multiple hormones secreted by adipocytes can profoundly alter energy metabolism in various tissues. Here, Combs and colleagues elucidate the primary metabolic effect of the latter hormone, also known as adiponectin. From earlier work, it appears that Acrp30 can sensitize animals to insulin?s effects on the liver and muscle; Combs et al. now find that when healthy mice are maintained for short periods at constant blood glucose and insulin levels, the presence of exogenous Acrp30 decreases hepatic glucose production. In particular, the authors show that glucose-6-phosphatase (G6Pase), an enzyme critical for hepatic glucose release, is less active in animals treated with exogenous Acrp30. At least during the 90-minute test period, this hormone has no appreciable effect on other aspects of energy metabolism, such as the rate of glucose consumption. Interestingly, Combs et al. show that mRNAs for G6Pase and a related gluconeogenic enzyme decline in the liver of Acrp30-treated animals. However, the effect on G6Pase activity seen in their physiological measurements probably occurs too quickly to be explained by a suppression of G6Pase transcription. Rather, this observation hints that Acrp30 exerts additional, long-term effects on energy metabolism by altering patterns of gene expression in the liver, and possibly in other target tissues as well.


Contact: John Ashkenas
Journal of Clinical Investigation

Page: 1

Related biology news :

1. Hormonal changes in satisfied and dissatisfied shift workers across a shift cycle
2. Hormonal changes during physiological development can alter immune response to viruses and infections
3. Hormonal recall
4. NIEHS And U.C. Davis Researchers Find Protein That May Be Key To Non-Hormonal Family Planning And Treatment Of Infertility
5. Hormonal Changes At Puberty Can Mask High Cholesterol In Blood
6. In gene regulation, small is beautiful
7. Infants sighs may reset breathing regulation mechanism as well as help lungs develop
8. Study reveals surprising remodeling property of gene regulation process
9. UCSD bioengineers develop first genome-scale computational model of gene regulation
10. Discoveries reveal that gene regulation is bipolar
11. Region of chromosome 1 important in blood pressure regulation

Post Your Comments:

(Date:8/14/2019)... (PRWEB) , ... August 14, 2019 , ... ... characterization, announced today that they have opened a Customer Experience Center (CEC) and ... need for the new office. , The Munich CEC will be a place ...
(Date:8/14/2019)... (PRWEB) , ... August 13, 2019 , ... ... Medicine Team, Division of Molecular Pathology, Institute of Cancer Research (ICR) in a ... BST/UK) to learn about the process of biomarker and companion diagnostic development including ...
(Date:8/6/2019)... Calif. (PRWEB) , ... August 06, 2019 , ... ... in veterinary stem cell manufacturing with clinical, regulatory and GMP manufacturing experience. ... Cells, Inc. (PSC). With extensive regulatory experience and one of the ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... August 13, 2019 , ... ... prepackaged mobile phases for QC laboratories. After gaining a few significant clients, Lifecycle ... approach into a valued supplier of manufacturing processing solutions, including reagents for tissue ...
(Date:8/6/2019)... Conn. (PRWEB) , ... August 06, 2019 , ... ... develops tools for characterizing microbiome populations down to the strain level, has announced ... microbiome kits and other products to companies and research organizations in Australia, Benelux, ...
(Date:7/30/2019)... ... July 30, 2019 , ... The summer season has been ... Not only has the company already hosted many of its signature cooking classes ... its guests. , With Lajollacooks4u’s Private Cooking Parties, guests prepare and enjoy a ...
(Date:7/19/2019)... ... July 18, 2019 , ... World renowned ... be joining forces with California-based charity Coalition Duchenne for its 9th Annual Expedition ... raises awareness and funding for Duchenne muscular dystrophy and was founded by Sabahan ...
Breaking Biology Technology:
Cached News: