HOME >> BIOLOGY >> NEWS
Hormone replacement therapy (HRT) may protect against cognitive decline in women 65 and older who have a certain genetic make-up

Researchers led by a UC San Francisco scientist are reporting that hormone replacement therapy (HRT) using estrogen may protect against cognitive decline in women 65 and older. The study of 3,393 women, to be published in the May 23 issue of Neurology, is the first to show that the genes a woman inherits can affect her response to estrogen.

Women who carry a certain variety of a gene called ApoE were half as likely to suffer cognitive deterioration after age 65 if they were using estrogen, said principal investigator Kristine Yaffe, MD, assistant professor of psychiatry, neurology and epidemiology at UCSF and chief of geriatric psychiatry at San Francisco Veterans Affairs Medical Center.

The ApoE (Apolipoprotein E) gene, which has three possible variants or alleles (e2, e3 and e4) is a blueprint for a protein that carries cholesterol and fats between the liver, brain and other tissues.

Estrogen-using women who carry the e2 and e3 variants (inherited as a pair from their parents) experienced less cognitive loss during the seven year study, said Yaffe. The results indicate that estrogen may help prevent cognitive decline in women who carry e2 and e3 alleles, she explained.

The researchers also studied women who carry at least one e4 allele and have a higher risk of developing Alzheimer's Disease (AD), according to previous studies. In these women, estrogen use did not protect against cognitive decline.

Yaffe also reports that estrogen use was associated with less carotid wall thickening or atherosclerosis. The carotid arteries located on either side of the neck carry blood to the brain. "Less atherosclerosis may prevent small vessel strokes that result in mental deterioration as we age," said Yaffe, adding that this mechanism needs further study.

The researchers studied women in four communities of the United States, who were part of the Cardiovascular Health Study (CHS), a long-term study of coronary heart disease and st
'"/>

Contact: Kevin Boyd
kboyd@pubaff.ucsf.edu
415-476-8429
University of California - San Francisco
22-May-2000


Page: 1 2

Related biology news :

1. Hormone helps fish to mate, may affect human hearing
2. Hormone linked to obesity plays positive role in fertility & possibly male arousal
3. Hormones, sand & terrorism
4. Hormone therapy could help prevent pre-term births
5. Hormones modify the type of proteins produced
6. Hormone replacement therapy may improve breast cancer detection and survival rate
7. Hormone found to reduce appetite by a third
8. Hormone replacement therapy may help prevent heart vessel disease, says Wake Forest researcher
9. Hormone replacement therapy may help prevent chronic wounds in elderly patients
10. Hormone therapy may boost quality of life, say Stanford researchers
11. APS hosts the "Genome and Hormone" Conference

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... ... Modality Solutions, a biopharmaceutical cold chain validation engineering firm, is pleased to ... most prestigious ranking of the nation’s fastest-growing private companies. Modality Solutions made the Inc. ... growth of 71 percent. , The Inc. 5000 list represents a unique look ...
(Date:8/21/2020)... LEXINGTON, Mass. (PRWEB) , ... August 18, 2020 ... ... novel approaches to cell therapy, today announced that the U.S. Food and Drug ... evaluation of Sentien’s lead asset, SBI-101, for the treatment of severe COVID-19. Approval ...
(Date:8/21/2020)... ... August 19, 2020 , ... ... and expo uniting life science, data science, informatics and IT leaders goes VIRTUAL ... this period of uncertainty and change, Bio-IT takes the leadership role of keeping ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... ... , ... Bio-IT World has announced the winners of the ... of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were honored. ... examples of how technology innovations and strategic initiatives can be powerful forces for ...
(Date:7/1/2020)... BOWLING GREEN, Ohio (PRWEB) , ... June 29, ... ... cooperative that offers access to competitively procured purchasing contracts to its membership, recently ... BioFit to provide TIPS members with the opportunity to purchase ergonomic seating, cafeteria ...
(Date:6/28/2020)... , ... June 25, 2020 , ... The Indoor Lab, ... of Safe Space™ for businesses of all types to ensure cleanliness, distancing and occupancy ... , A Safe Space™ enabled business will provide a health performance index system ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... cancer, today announced the company has entered a license agreement with Roswell Park ... Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a novel medical ...
Breaking Biology Technology:
Cached News: