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Hormone replacement therapy (HRT) may protect against cognitive decline in women 65 and older who have a certain genetic make-up

roke in older adults. Mental function tests, given in each of five to seven years, tracked cognitive decline in women who were asked to report estrogen use on a questionnaire given during each visit. Nearly all of the women gave blood samples containing the DNA necessary for ApoE genotyping.

At each testing point, results were adjusted for factors that vary between estrogen users and non-users (age, education, alcohol consumption habits and body mass) and other risk factors for cognitive decline (age, education, race and stroke history). The researchers excluded the small number of women taking progestins and were not able to determine if estrogen taken with progestins would have the same effect on cognitive decline. Yaffe cautions that more study is also necessary to determine whether HRT taken before age 65 can prevent cognitive decline.


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Contact: Kevin Boyd
kboyd@pubaff.ucsf.edu
415-476-8429
University of California - San Francisco
22-May-2000


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