HOME >> BIOLOGY >> NEWS
Hormones modify the type of proteins produced

HOUSTON -- (Oct. 11, 2002) -- Naturally occurring hormones such as estrogen, progesterone and cortisol play an important role in determining what kind of protein the cell makes in response to a genetic message, said researchers at Baylor College of Medicine in a report in today's issue of the journal Science.

"These steroid hormones are some of the things that change the protein that comes from a gene," said Dr. Bert O'Malley, chairman of cellular and molecular biology at Baylor and senior author of the paper. The other authors include Drs. Susan Berget, interim chairman of the department of pharmacology at Baylor, Dider Auboef, instructor in cell biology and Arnd Honig, currently of the University of Tubingen in Germany.

When a gene is activated, its DNA is transcribed or translated into messenger RNA, which carries the message about which protein is to be made to the assembly apparatus of the cell. However, one gene can produce different kinds of messenger RNAs, resulting in different proteins. The process is called "alternative splicing."

"This explains how 30,000 human genes can result in more than 100,000 proteins," said O'Malley.

O'Malley and his colleagues found that hormones achieve this effect by binding to their specific receptors in the cell. The receptors then find the appropriate genes and recruit a specific set of molecules called "co-activators." These co-activators then find splicing factors that govern which portions of the gene are included in the messenger RNA. The message the RNA carries determine the kind of protein that is made.

The co-activators can both change the amount of the gene's message and also change the protein it causes to be produced.

"It points out the tremendous power of hormones," said O'Malley. "Maybe when hormones do bad or good, it is not because they make too much or too little of a protein but because they make the wrong kind of protein. This could relate to anythin
'"/>

Contact: Lori Williams
loriw@bcm.tmc.edu
713-798-4712
Baylor College of Medicine
10-Oct-2002


Page: 1 2

Related biology news :

1. Hormones, sand & terrorism
2. Study Suggests Maternal Stress And Stress Hormones May Influence Fetal Brain Development In Utero
3. Hormones Found In The Brain May Determine How Much You Eat And Affect Obesity And Diabetes
4. Study explores gene transfer to modify underlying course of Alzheimers disease
5. Study suggests genetically modifying sunflowers for white mold resistance
6. UCR scientists modify existing chemical scrubber to environmentally friendly, all-natural filter
7. Scientists discover chromatin-modifying enzyme crucial for normal development
8. Selected estrogen compounds modify risks of vein clotting, a response to hormone replacement theraphy
9. NICHD funded researchers first to genetically modify non human primate
10. Oregon Health Sciences University researchers take steps to genetically modify monkeys for the research of human disease
11. New molecular link key to cellular proteins involved in cancer progression, other diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 02, 2020 , ... Dutch ... the use of its revolutionary NEXTGENPCR endpoint thermocycler to test for SARS-CoV-2 ... The article, titled "Ultra-fast one-step RT-PCR protocol for the detection of SARS-CoV-2," ...
(Date:6/28/2020)... ... ... In an upcoming episode scheduled for the fall of 2020, Advancements with ... Check local listings for more info. , Today, the majority of testing is performed ... throughout the country. Results are then available several days later. Now, in an effort ...
(Date:6/23/2020)... (PRWEB) , ... June 22, 2020 , ... The field ... Typically, ligand binding assays (LBA) have dominated this area. However, the use of mass ... years. , This now necessitates the question “How do you choose which approach to ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now offering patients ... million stem cells total, patients may choose which extremities they would like treated. , ... (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from a ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... and Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing ... announced that they have entered into a strategic partnership whereby Catalent will provide ...
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed Tech , Gary ... in a one hour live webinar on Thursday, August 13, 2020 at ... drugs and medical devices. Specifically, for medical devices, the NMPA has departments dealing with ...
(Date:7/18/2020)... ... July 17, 2020 , ... ... for the life sciences and food industries, is pleased to announce that Charles ... Research – Business Development. , Charles is an accomplished and results-driven sales executive ...
Breaking Biology Technology:
Cached News: