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Host gene that makes people vulnerable to leprosy discovered

Montreal (February 10, 2003) An international research team, led by Dr. Erwin Schurr and Dr. Thomas Hudson, Scientists at the Research Institute of the McGill University Health Centre, have identified a gene on human chromosome 6 that makes people vulnerable to leprosy. The study will be published in the March 2003 issue of Nature Genetics.

"This discovery will now allow us to study how the gene works and how it influences the infectious process. This is an important step toward the development of innovative prevention and treatment strategies for leprosy", stated Dr. Schurr.

"Leprosy has plagued humans for many centuries and it continues to be a concern in many countries," stated Dr. Marcel Behr, Infectious Disease Specialist at the MUHC and Assistant Professor of Medicine at McGill University. "These studies lead the way to developing better treatment and a possible vaccine."

Leprosy, a chronic disease caused by infection with the bacteria Mycobacterium leprae, affects approximately one million people worldwide. While it is a rare disease in Canada and the United States, the World Health Organization has identified 91 countries in which leprosy infection is highly prevalent. Symptoms of leprosy include pigmented skin lesions, permanent nerve damage leading to numbness of the feet and hands and, if left untreated, the disease may result in gross disfiguration including loss of finger, toes, feet and hands. The leprosy bacteria are transmitted through direct personal contact or contaminated respiratory droplets.

Schurr and his colleagues used a technique called "genome scanning" to map the gene. The research team analyzed DNA samples from nearly 100 families who were susceptible to the disease, and found that the families shared a common gene variant on chromosome 6. They then analyzed the DNA of an additional 200 families with leprosy to confirm their findings. "In the last few years advances in technology have made complex
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Contact: Christine Zeindler
christine.zeindler@muhc.mcgill.ca
514-934-1934
McGill University
9-Feb-2003


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