How Nerve Cells Get In Touch - A Molecular Model Of Synapse Formation And Retrograde Signalling In The Brain

Researchers at the Max Planck Institute for Experimental Medicine, Göttingen/Germany, and at the University of Texas Southwestern Medical Center, Dallas/Texas, characterized a novel family of cell surface proteins that may regulate the generation of functional networks between nerve cells in the brain by inducing synapse formation (Proc. Natl. Acad. Sci. USA 96, 1100-1105; Feb. 2, 1999).

Information in the brain is transmitted at synapses which are highly sophisticated contact zones between a sending and a receiving nerve cell. They have a typical asymmetric structure where the sending, presynaptic part is specialized for the secretion of neurotransmitters and other signalling molecules while the receiving, postsynaptic part is composed of a complex signal transduction machinery.

In the developing human embryo, cell recognition mechanisms with high resolution generate an ordered network of some 1015 synapses, linking about 1012 nerve cells. The extraordinary specificity of synaptic connections in the adult brain is generated in five consecutive steps. Initially, immature nerve cells migrate to their final location in the brain (1). There, they form processes, so called axons. Axons grow, often over quite long distances, into the target region that the corresponding nerve cell is supposed to hook up with (2). Once arrived in the target area, an axon selects its target cell from a large number of possible candidates (3). Next, a synapse is formed at the initial site of contact between axon and target cell. For this purpose, specialized proteins are recruited to the synaptic contact zone (4). Newly formed synapses are then stabilized and modulated, depending on their use (5). These processes result in finely tuned networks of nerve cells that mediate all brain functions, ranging from simple movements to complex cognitive or emotional behaviour.

Until very recently, the molecular mechanisms that regulate synapse formation in the developing brain w

Contact: Nils Brose

Page: 1 2 3

Related biology news :

1. Nerve cells guided to repair spinal damage: Technique
2. Nerves, heal thyselves
3. Nerve disorder in mice and men linked to mutated gene
4. Never too late to boogie: Nerve cells still active in mature brain
5. Nerve cells death different from other cells
6. Nerve protein shown crucial to sensations of pain from heat, injury
7. Nerve cells with stoppage: Evidence for a molecular key step in the process of signal transduction between nerve cells
8. Scientists Discover Protein In Mammals Tuned To Respond To What May Be Hottest Temperature Our Nerves Can Detect
9. Nerve Cells On The Go
10. Human/Insect/Jellyfish Genes Team To Quiet "Hyper" Nerve Cells
11. Small G-Proteins Make A Big Difference -- Nerve Cell Signalling Is Regulated By Arf-GTPases And Their Activators

Post Your Comments:

(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: