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How Super Are The "Super Aspirins"? -- New COX-2 Inhibitors May Elevate Cardiovascular Risk

isease patients to reduce the odds of thrombotic events. The COX-2 inhibitors do not offer this additional protective action while they do remove the body's inherent ability to control platelet aggregation through prostacyclin production.

"One option may be for patients who are at particular risk for adverse cardiovascular events to combine COX-2 therapies with low-dose aspirin," FitzGerald suggests. "But this is a strategy that would need to be tested in clinical trials."

The current study was performed with Celebrex, the COX-2 compound from G. D. Searle and Co. that was approved for sale on December 31, 1998, by the Food and Drug Administration. FitzGerald notes, however, that the potential risk factor identified in the experiments done in his laboratory is not a property solely of Celebrex. Results of a study involving Vioxx, a COX-2 inhibitor from Merck & Co., have shown similar results, he says.

The lead author on the study is B. F. McAdam, MD. In addition to senior author FitzGerald, the remaining authors are F. Catella-Lawson, MD; I. A. Mardini, MD; S. Kapoor, PhD; and J. A. Lawson, BS. Funding for the study was provided by G. D. Searle and Co.


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Contact: Franklin Hoke
hokef@mail.med.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
14-Jan-1999


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